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Rethinking mucosal antibody responses: IgM, IgG and IgD join IgA.
Nature Reviews Immunology ( IF 67.7 ) Pub Date : 2020-02-03 , DOI: 10.1038/s41577-019-0261-1
Kang Chen 1 , Giuliana Magri 2 , Emilie K Grasset 3, 4 , Andrea Cerutti 2, 3, 5
Affiliation  

Humoral immune responses at mucosal surfaces have historically focused on IgA. Growing evidence highlights the complexity of IgA-inducing pathways and the functional impact of IgA on mucosal commensal bacteria. In the gut, IgA contributes to the establishment of a mutualistic host-microbiota relationship that is required to maintain homeostasis and prevent disease. This Review discusses how mucosal IgA responses occur in an increasingly complex humoral defence network that also encompasses IgM, IgG and IgD. Aside from integrating the protective functions of IgA, these hitherto neglected mucosal antibodies may strengthen the communication between mucosal and systemic immune compartments.

中文翻译:


重新思考粘膜抗体反应:IgM、IgG 和 IgD 加入 IgA。



粘膜表面的体液免疫反应历来集中于 IgA。越来越多的证据强调了 IgA 诱导途径的复杂性以及 IgA 对粘膜共生细菌的功能影响。在肠道中,IgA 有助于建立宿主-微生物群的互惠关系,这是维持体内平衡和预防疾病所必需的。本综述讨论了粘膜 IgA 反应如何在日益复杂的体液防御网络中发生,该网络还包括 IgM、IgG 和 IgD。除了整合 IgA 的保护功能外,这些迄今为止被忽视的粘膜抗体还可以加强粘膜和全身免疫区室之间的沟通。
更新日期:2020-02-03
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