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EMT signaling: potential contribution of CRISPR/Cas gene editing.
Cellular and Molecular Life Sciences ( IF 7.014 ) Pub Date : 2020-02-01 , DOI: 10.1007/s00018-020-03449-3
Reza Mohammadinejad,Alessio Biagioni,Ganesan Arunkumar,Rebecca Shapiro,Kun-Che Chang,Mohammed Sedeeq,Aftab Taiyab,Mohammad Hashemabadi,Abbas Pardakhty,Ali Mandegary,Jean-Paul Thiery,Amir Reza Aref,Iman Azimi

Epithelial to mesenchymal transition (EMT) is a complex plastic and reversible cellular process that has critical roles in diverse physiological and pathological phenomena. EMT is involved in embryonic development, organogenesis and tissue repair, as well as in fibrosis, cancer metastasis and drug resistance. In recent years, the ability to edit the genome using the clustered regularly interspaced palindromic repeats (CRISPR) and associated protein (Cas) system has greatly contributed to identify or validate critical genes in pathway signaling. This review delineates the complex EMT networks and discusses recent studies that have used CRISPR/Cas technology to further advance our understanding of the EMT process.
更新日期:2020-02-04

 

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