Epithelial to mesenchymal transition (EMT) is a complex plastic and reversible cellular process that has critical roles in diverse physiological and pathological phenomena. EMT is involved in embryonic development, organogenesis and tissue repair, as well as in fibrosis, cancer metastasis and drug resistance. In recent years, the ability to edit the genome using the clustered regularly interspaced palindromic repeats (CRISPR) and associated protein (Cas) system has greatly contributed to identify or validate critical genes in pathway signaling. This review delineates the complex EMT networks and discusses recent studies that have used CRISPR/Cas technology to further advance our understanding of the EMT process.

中文翻译：

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EMT 信号传导：CRISPR/Cas 基因编辑的潜在贡献。


上皮间质转化（EMT）是一种复杂的可塑性和可逆的细胞过程，在多种生理和病理现象中发挥着关键作用。 EMT参与胚胎发育、器官发生和组织修复，以及纤维化、癌症转移和耐药性。近年来，使用成簇规则间隔回文重复序列 (CRISPR) 和相关蛋白 (Cas) 系统编辑基因组的能力极大地有助于识别或验证通路信号传导中的关键基因。这篇综述描述了复杂的 EMT 网络，并讨论了最近使用 CRISPR/Cas 技术来进一步加深我们对 EMT 过程的理解的研究。