Sleep duration, brain structure, and psychiatric and cognitive problems in children.,Molecular Psychiatry

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Sleep duration, brain structure, and psychiatric and cognitive problems in children.
Molecular Psychiatry ( IF 9.6 ) Pub Date : 2020-02-03 , DOI: 10.1038/s41380-020-0663-2
Wei Cheng _{1,

2} , Edmund Rolls _{1,

3,

4} , Weikang Gong ₅ , Jingnan Du _{1,

2} , Jie Zhang _{1,

2} , Xiao-Yong Zhang _{1,

2} , Fei Li ₆ , Jianfeng Feng _{1,

2,

3}

Affiliation

Low sleep duration in adults is correlated with psychiatric and cognitive problems. We performed for the first time a large-scale analysis of sleep duration in children, and how this relates to psychiatric problems including depression, to cognition, and to brain structure. Structural MRI was analyzed in relation to sleep duration, and psychiatric and cognitive measures in 11,067 9-11-year-old children from the Adolescent Brain Cognitive Development (ABCD) Study, using a linear mixed model, mediation analysis, and structural equation methods in a longitudinal analysis. Dimensional psychopathology (including depression, anxiety, impulsive behavior) in the children was negatively correlated with sleep duration. Dimensional psychopathology in the parents was also correlated with short sleep duration in their children. The brain areas in which higher volume was correlated with longer sleep duration included the orbitofrontal cortex, prefrontal and temporal cortex, precuneus, and supramarginal gyrus. Longitudinal data analysis showed that the psychiatric problems, especially the depressive problems, were significantly associated with short sleep duration 1 year later. Further, mediation analysis showed that depressive problems significantly mediate the effect of these brain regions on sleep. Higher cognitive scores were associated with higher volume of the prefrontal cortex, temporal cortex, and medial orbitofrontal cortex. Public health implications are that psychopathology in the parents should be considered in relation to sleep problems in children. Moreover, we show that brain structure is associated with sleep problems in children, and that this is related to whether or not the child has depressive problems.

中文翻译：

儿童的睡眠时间、大脑结构以及精神和认知问题。

成人睡眠时间短与精神和认知问题相关。我们首次对儿童的睡眠持续时间进行了大规模分析，以及这与精神问题（包括抑郁症）、认知和大脑结构之间的关系。在青少年大脑认知发展 (ABCD) 研究中，使用线性混合模型、中介分析和结构方程方法分析了结构 MRI 与睡眠持续时间、精神和认知测量的关系，研究对象为 11,067 名 9-11 岁儿童纵向分析。儿童的维度精神病理学（包括抑郁、焦虑、冲动行为）与睡眠时间呈负相关。父母的多维精神病理学也与孩子的睡眠时间短有关。较高容量与较长睡眠时间相关的大脑区域包括眶额皮质、前额叶和颞叶皮质、楔前叶和缘上回。纵向数据分析表明，精神问题，尤其是抑郁问题，与 1 年后的睡眠持续时间短显着相关。此外，中介分析表明，抑郁问题显着调节这些大脑区域对睡眠的影响。较高的认知分数与较高的前额叶皮层、颞叶皮层和内侧眶额叶皮层体积相关。对公共卫生的影响是，父母的精神病理学应该与儿童的睡眠问题联系起来考虑。此外，我们表明大脑结构与儿童的睡眠问题有关，

更新日期：2020-02-04

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