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Obesity in adolescents and cancer risk: causal relationship or epiphenomenon?
The Lancet Diabetes & Endocrinology ( IF 44.0 ) Pub Date : 2020-02-03 , DOI: 10.1016/s2213-8587(20)30028-0 Thomas Reinehr 1
The Lancet Diabetes & Endocrinology ( IF 44.0 ) Pub Date : 2020-02-03 , DOI: 10.1016/s2213-8587(20)30028-0 Thomas Reinehr 1
Affiliation
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Obesity is increasing worldwide in children and adolescents. Furthermore, there has been an alarming increase in the degree of obesity, resulting in extreme obesity in youth. This increase in prevalence and degree of obesity has been linked to increased cardiovascular morbidity and mortality. In addition to this well-known consequence of adolescent obesity, a further relevant complication has been identified by Ariel Furer and colleagues in The Lancet Diabetes & Endocrinology. To my knowledge, this is the first study to report the overall morbidity and mortality of all cancers in a long-term follow-up (45 years) of a large nationwide representative cohort (more than 2·3 million Israeli adolescents). Body-mass index (BMI) at age 17 years was associated with an increased risk of mortality and morbidity for all cancers (except premenopausal breast and cervical cancer) at age 30 years. It should be highlighted that the risk for later cardiovascular events was higher than for cancer in the same study cohort. The strongest associations between adolescent BMI and specific cancer types were observed for gastrointestinal, breast, and kidney cancers for men and uterus, ovarian, and gastrointestinal cancers among women. These findings must be confirmed in other independent studies in different populations, since cancer risk differs across different ethnicities.
中文翻译：
青少年肥胖与癌症风险：因果关系或表观现象？
肥胖在世界范围内在儿童和青少年中正在增加。此外，肥胖程度急剧增加，导致青年时期的极端肥胖。肥胖症患病率和肥胖程度的增加与心血管疾病的发病率和死亡率增加有关。除了青少年肥胖的众所周知的后果外，《柳叶刀》糖尿病与内分泌学的Ariel Furer及其同事还发现了其他相关并发症。。据我所知，这是第一项针对全国范围内有代表性的大型队列（超过200万名以色列青少年）进行的长期随访（45年）报告所有癌症的总体发病率和死亡率的研究。17岁时的身体质量指数（BMI）与30岁时所有癌症（绝经前乳腺癌和宫颈癌除外）的死亡率和发病率增加风险相关。应该强调的是，在同一研究队列中，以后发生心血管事件的风险高于发生癌症的风险。在男性，女性的胃肠道癌，乳腺癌和肾癌中，观察到青春期BMI与特定癌症类型之间的最强关联。这些发现必须在不同人群的其他独立研究中得到证实，
更新日期：2020-02-19
中文翻译：
青少年肥胖与癌症风险：因果关系或表观现象？
肥胖在世界范围内在儿童和青少年中正在增加。此外，肥胖程度急剧增加，导致青年时期的极端肥胖。肥胖症患病率和肥胖程度的增加与心血管疾病的发病率和死亡率增加有关。除了青少年肥胖的众所周知的后果外，《柳叶刀》糖尿病与内分泌学的Ariel Furer及其同事还发现了其他相关并发症。。据我所知，这是第一项针对全国范围内有代表性的大型队列（超过200万名以色列青少年）进行的长期随访（45年）报告所有癌症的总体发病率和死亡率的研究。17岁时的身体质量指数（BMI）与30岁时所有癌症（绝经前乳腺癌和宫颈癌除外）的死亡率和发病率增加风险相关。应该强调的是，在同一研究队列中，以后发生心血管事件的风险高于发生癌症的风险。在男性，女性的胃肠道癌，乳腺癌和肾癌中，观察到青春期BMI与特定癌症类型之间的最强关联。这些发现必须在不同人群的其他独立研究中得到证实，
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