Modern medicine has undoubtedly achieved enormous progress in applying various polymer-based materials for specific applications. Despite this, there is still a need to create systems, especially on the nano-scale, that are simultaneously nontoxic, biocompatible and able to be functionalized with active biomolecules. Polyglycidol (also called polyglycerol) is biocompatible and hydrophilic polymer, that forms different, sometimes complex, polymer architecture, possesses satisfactory stability and has a hydroxyl group on each unit capable for numerous modifications. All of these are undisputed advantages of this polymer. The potential application of this polymer and its derivatives in e.g. macromolecular therapeutics, bioconjugation with peptides, and as drug delivery systems or imaging agents has been examined and described. Nowadays, due to the possibility of using advanced synthetic methodologies, the development of new systems or devices based on polyglycidol is possible for well-defined applications. This review summarizes the results concerning the covalent immobilization of polyglycidol of linear and branched architecture on different 2 D or 3 D supports. A comprehensive overview is provided in relation to the synthetic strategy, properties of polyglycidol layers, its modification and application in reconstructive medicine or tissue engineering as antifouling surfaces, surfaces for cell engineering and imaging or for the immobilization of bioactive compounds.

在将各种基于聚合物的材料用于特定应用方面，现代医学无疑取得了巨大的进步。尽管如此，仍然需要创建特别是在纳米级的系统，其同时无毒，生物相容并且能够用活性生物分子功能化。聚缩水甘油（也称为聚甘油）是生物相容性和亲水性聚合物，可形成不同的，有时复杂的聚合物结构，具有令人满意的稳定性，并且每个单元上均具有能够进行多种修饰的羟基。所有这些都是该聚合物无可争议的优势。已经研究和描述了该聚合物及其衍生物在例如大分子疗法，与肽的生物缀合中以及作为药物递送系统或显像剂的潜在应用。如今，由于使用先进的合成方法的可能性，基于聚缩水甘油的新系统或装置的开发对于明确的应用是可能的。这篇综述总结了关于在不同的2D或3D载体上共价固定线性和支链结构的聚缩水甘油的结果。提供了有关合成策略，聚缩水甘油层的特性，其在防污表面，细胞工程和成像表面或生物活性化合物固定化方面在改性医学或组织工程中的修饰和应用的全面概述。这篇综述总结了关于在不同的2D或3D载体上共价固定线性和支链结构的聚缩水甘油的结果。提供了有关合成策略，聚缩水甘油层的特性，其在防污表面，细胞工程和成像表面或生物活性化合物固定化方面在改性医学或组织工程中的修饰和应用的全面概述。这篇综述总结了关于在不同的2D或3D载体上共价固定线性和支链结构的聚缩水甘油的结果。提供了有关合成策略，聚缩水甘油层的特性，其在防污表面，细胞工程和成像表面或生物活性化合物固定化方面在改性医学或组织工程中的修饰和应用的全面概述。