To investigate the role of lymphotoxin (LT) in Sjögren's syndrome (SS) and in mucosal associated lymphoid tissue (MALT)-lymphoma, we made transgenic mice (Amy1-LTαβ) that targeted LTα and LTβ to the salivary and lacrimal glands. Amy1-LTαβ mice developed atrophic salivary and lacrimal glands that contained tertiary lymphoid organs (TLOs) and had reduced tear production. Amy1-LTαβ mice developed cervical lymphadenopathy but not MALT-lymphoma. TLO formation in the salivary and lacrimal glands of Amy1-LTαβ was not sufficient to induce autoimmunity as measured by autoantibody titres.

中文翻译：

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靶向唾液和泪腺的淋巴毒素诱导第三淋巴器官和宫颈淋巴结病，并减少泪液产生。

为了研究淋巴毒素（LT）在干燥综合征（SS）和黏膜相关淋巴样组织（MALT）淋巴瘤中的作用，我们制备了将LTα和LTβ靶向唾液和泪腺的转基因小鼠（Amy1-LTαβ）。Amy1-LTαβ小鼠出现了萎缩的唾液和泪腺，其中含有第三淋巴器官（TLO），并且泪液产生减少。Amy1-LTαβ小鼠发展为颈淋巴结病，但未发展成MALT淋巴瘤。通过自身抗体滴度测量，Amy1-LTαβ唾液和泪腺中的TLO形成不足以诱导自身免疫。