This investigation describes the synthesis of a dual stimuli‐responsive, amphiphilic ABC tri‐block copolymer (BCP) based on the functional monomers via RAFT polymerization. In this case, ABC‐type BCP was prepared based on N‐isopropylacrylamide, n‐butyl acrylate, and 4‐vinylpyridine in DMF solvent using cyanomethyl dodecyl trithiocarbonate as the RAFT agent and azobisisobutyronitrile as a thermal initiator in a subsequent macro‐RAFT approach, respectively. The BCPs were characterized by SEC, ¹H‐NMR, FTIR spectroscopy, and DSC analyses. Temperature and pH‐dependent properties of the smart BCP micelles in aqueous medium were investigated using dynamic light scattering. Transmission electron microscopic images were taken at cryogenic and dry conditions to study the morphology of molecular assemblies of block copolymers in an aqueous medium. The phase and topographical images were captured by atomic force microscopy to understand the assembly of block copolymers in solvents of different polarities. The morphology of BCP micelles was transformed from flower‐like to spherical in the presence of solvents with different polarities (H₂O or CHCl₃).

中文翻译：

---

量身定制的ABC型两亲三嵌段共聚物的双重刺激响应自组装行为

这项研究描述了通过RAFT聚合基于功能单体合成双刺激，两亲性ABC三嵌段共聚物（BCP）。在这种情况下，ABC型BCP是基于N-异丙基丙烯酰胺，丙烯酸正丁酯和4-乙烯基吡啶在DMF溶剂中制备的，使用氰基甲基十二烷基三硫代碳酸酯作为RAFT试剂，偶氮二异丁腈作为热引发剂，随后采用大分子RAFT方法，分别。BCP具有SEC的特征¹H-NMR，FTIR光谱和DSC分析。使用动态光散射研究了水性介质中智能BCP胶束的温度和pH依赖性。在低温和干燥条件下拍摄透射电子显微镜图像，以研究含水介质中嵌段共聚物分子组装的形态。通过原子力显微镜捕获相图和形貌图，以了解嵌段共聚物在不同极性溶剂中的组装。在极性不同的溶剂（H ₂ O或CHCl ₃）存在下，BCP胶束的形态从花样转变为球形。