Glaesserella (formerly Haemophilus) parasuis causes Glässer's disease, which results in high economic loss in the swine industry. To understand the polymicrobial interactions of G. parasuis and the nasal microbiota, the statistical association patterns of nasal colonizing bacteria with virulent and non-virulent strains of G. parasuis were studied accounting for the farm management practices as potential risk factors for the occurrence of Glässer's disease. The nasal microbiota from 51 weaned-piglets from four farms with Glässer's disease and three farms with no respiratory diseases was previously characterized and included in this study. The presence of virulent and/or non-virulent G. parasuis strains in the nasal cavities was determined in order to establish the potential association with other members of the nasal microbiota. Multivariate logistic and linear regression models were performed among the various members of nasal microbiota and G. parasuis. The multi-site production system and disease presence in the farm were both significantly associated with the presence of G. parasuis virulent strains in the nose of the piglets. Differential bacterial associations were observed with virulent or non-virulent G. parasuis. Chitinophagaceae, Corynebacteriaceae and Corynebacterium were positively associated with the virulent G. parasuis strains, while Enterobacteriaceae, Peptostreptococcaceae, Clostridium XI, and Escherichia/Shigella were negatively associated with virulent G. parasuis. On the other hand, Flavobacteriaceae, Planobacterium, and Phascolarctobacterium were positively associated with the non-virulent G. parasuis strains, while Rikenellaceae, Enterococcaceae, Odoribacter, and Corynebacterium were negatively associated with non-virulent G. parasuis. In conclusion, the nasal microbiota communities showed variations in the association with the G. parasuis strains type.

中文翻译：

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断奶仔猪鼻微生物群与副产格拉斯氏菌（嗜血杆菌）的毒力和非毒力菌株的关联变化。

副猪Glaesserella（原称嗜血杆菌）会引起格拉塞尔氏病，这在养猪业中造成很高的经济损失。为了了解副猪嗜血杆菌和鼻腔菌群之间的微生物相互作用，研究了鼻定殖细菌与副猪嗜血杆菌的有毒和无毒力菌株之间的统计关联模式，从而将农场管理方法解释为发生了格拉瑟氏菌的潜在危险因素。疾病。先前已对来自四个患有Glässer病的农场和三个没有呼吸系统疾病的农场的51只断奶仔猪的鼻微生物群进行了表征，并将其纳入本研究。为了确定与鼻微生物群其他成员的潜在联系，确定了在鼻腔中是否存在强毒和/或无毒副猪嗜血杆菌。在鼻微生物群和副猪嗜血杆菌的各个成员之间进行了多元逻辑和线性回归模型。猪场中的多站点生产系统和疾病的存在都与猪鼻中副猪乳杆菌强毒株的存在密切相关。在强毒或无毒副猪嗜血杆菌中观察到不同的细菌缔合。甲壳菌科，棒杆菌科和棒杆菌与强毒副猪链菌正相关，而肠杆菌科，肽链球菌，梭状芽孢杆菌和大肠杆菌/志贺氏菌与强毒副猪链负相关。另一方面，黄杆菌科，平杆菌属和杆菌杆菌与无毒副猪嗜血杆菌正相关，而里肯氏菌科，肠球菌科，敖德罗杆菌和棒状杆菌与无毒副猪嗜血杆菌负相关。总之，鼻微生物群落与副猪嗜血杆菌菌株类型相关。