BACKGROUND Prior research on accelerated knee osteoarthritis (AKOA) was primarily confined to the Osteoarthritis Initiative, which was enriched with people with risk factors for knee osteoarthritis (KOA). It is unclear how often AKOA develops in a community-based cohort and whether we can replicate prior findings from the Osteoarthritis Initiative in another cohort. Hence, we determined the incidence and characteristics of AKOA among women in the Chingford Study, which is a prospective community-based cohort. METHODS The Chingford Study had 1003 women with quinquennial knee radiographs over 15 years. We divided the 15-year observation period into three consecutive 5-year phases. Within each 5-year phase, we selected 3 groups of participants among women who started a phase without KOA (Kellgren-Lawrence [KL] < 2): 1) incident AKOA developed KL grade ≥ 3, 2) typical KOA increased radiographic scoring (excluding AKOA), and 3) no KOA had the same KL grade over time. Study staff recorded each participant's age, body mass index (BMI), and blood pressure at baseline, 5-year, and 10-year study visits. We used multinomial logistic regression models to test the association between groups (outcome) and age, BMI, and blood pressure at the start of each phase. The cumulative incidences and odds ratios (OR) from each phase were pooled using a fixed-effect meta-analysis model. RESULTS The person-based cumulative incidence of AKOA was 3.9% over 5 years (pooled estimate across the three 5-year phases). Among incident cases of KOA, AKOA represented ~ 15% of women with incident KOA. Women with AKOA were older than those with typical (OR = 1.56, 95%CI = 1.16-2.11) or no KOA (OR = 1.84, 95%CI = 1.40-2.43). Women with AKOA had a greater BMI than those without KOA (OR = 1.52, 95%CI = 1.17-1.97). We observed no association between group and blood pressure. CONCLUSIONS In a community-based cohort, > 1 in 7 women with incident KOA had AKOA. Like the Osteoarthritis Initiative, people with AKOA were more likely to have greater age and BMI.

中文翻译：

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女性加速膝骨关节炎的发病率和特征：Chingford队列。

背景技术关于加速膝关节骨关节炎（AKOA）的先前研究主要限于骨关节炎计划，该计划丰富了具有膝骨关节炎（KOA）危险因素的人。目前尚不清楚AKOA在以社区为基础的队列中多久发展一次，我们是否可以在另一个队列中复制骨关节炎倡议的先前发现。因此，我们在Chingford研究中确定了女性中AKOA的发病率和特征，这是一项基于社区的前瞻性研究。方法Chingford研究对1003名女性进行了15年的五年期膝部X光片检查。我们将15年的观察期分为三个连续的5年阶段。在每个5年阶段中，我们从没有KOA（Kellgren-Lawrence [KL] <2）开始阶段的女性中选择了3组参与者：1）事件AKOA的KL等级≥3，2）典型的KOA放射评分更高（不包括AKOA），3）随着时间的推移，没有KOA具有相同的KL等级。研究人员在基线，5年和10年研究访视时记录每个参与者的年龄，体重指数（BMI）和血压。我们使用多项逻辑回归模型来测试各阶段开始时各组（结果）与年龄，BMI和血压之间的关联。使用固定效应荟萃分析模型汇总每个阶段的累积发生率和比值比（OR）。结果基于人的AKOA累积发生率在5年中为3.9％（三个5年阶段的合并估算值）。在发生KOA的事件中，约有15％的KOA妇女占AKOA的比例。患有AKOA的女性比典型女性大（OR = 1.56，95％CI = 1.16-2。11）或没有KOA（OR = 1.84，95％CI = 1.40-2.43）。患有AKOA的女性的BMI高于未患有KOA的女性（OR = 1.52，95％CI = 1.17-1.97）。我们观察到组和血压之间没有关联。结论在一个社区队列中，每7名发生KOA的妇女中有1名患有AKOA。像骨关节炎倡议一样，患有AKOA的人更可能具有更大的年龄和BMI。