BACKGROUND The mean platelet volume (MPV) is an important indicator of platelet function with large platelets showing higher enzymatic and metabolic activity than other platelets. There can be a relationship between increased platelet activity and anxiety and depression. Our primary hypothesis was that patients with high anxiety scores would have higher MPV, and the secondary hypothesis was that propofol induction time and total propofol consumption within the first 30 min of surgery would be higher in patients with higher anxiety scores. METHODS The Beck Anxiety Inventory (BAI) was administered to the participating patients 1 day before surgery to evaluate the level of anxiety. Based on the scores from the BAI, 40 patients with an anxiety score of < 8 were assigned to the non-anxious group (Group NA) and 40 patients with an anxiety score of ≥8 were assigned to the anxious group (Group A). At the anesthesia induction the mean time to achieve an entropy value below 60 (T1) was recorded. The total intraoperative propofol consumption within the first 30 min was recorded. RESULTS There was a statistically significant difference between the groups in terms of preoperative MPV and demographic data, including age and sex. The mean total propofol consumption at 30 min after induction in the groups was statistically significant. The cut-off value for MPV was calculated as 9.65. CONCLUSIONS The preoperative MPV values and propofol consumption at 30 min among patients with high preoperative anxiety scores were high. We suggest that MPV is helpful in the clinical practice in predicting the amount of anesthetic agents required for the 30 mins of anesthesia.

中文翻译：

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术前焦虑水平对平均血小板体积和丙泊酚消耗量的影响。


背景技术平均血小板体积（MPV）是血小板功能的重要指标，大血小板比其他血小板表现出更高的酶活性和代谢活性。血小板活性增加与焦虑和抑郁之间可能存在关联。我们的主要假设是焦虑评分高的患者 MPV 较高，次要假设是焦虑评分较高的患者异丙酚诱导时间和手术前 30 分钟内的异丙酚总消耗量较高。方法在手术前1天对参与的患者进行贝克焦虑量表（BAI）以评估焦虑水平。根据BAI的评分，40名焦虑评分<8的患者被分配到非焦虑组（NA组），40名焦虑评分≥8的患者被分配到焦虑组（A组）。记录麻醉诱导时熵值达到低于 60 (T1) 的平均时间。记录前30分钟内术中丙泊酚总消耗量。结果 各组之间在术前 MPV 和人口统计数据（包括年龄和性别）方面存在统计学显着差异。诱导后 30 分钟各组的平均异丙酚总消耗量具有统计学意义。 MPV 的截止值为 9.65。结论 术前焦虑评分高的患者术前 MPV 值和 30 min 丙泊酚消耗量较高。我们认为 MPV 在临床实践中有助于预测 30 分钟麻醉所需的麻醉剂用量。