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High-Speed Single-Cell Dielectric Spectroscopy.
ACS Sensors ( IF 8.2 ) Pub Date : 2020-02-17 , DOI: 10.1021/acssensors.9b02119 Daniel Spencer 1 , Hywel Morgan 1
ACS Sensors ( IF 8.2 ) Pub Date : 2020-02-17 , DOI: 10.1021/acssensors.9b02119 Daniel Spencer 1 , Hywel Morgan 1
Affiliation
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Single-cell impedance cytometry is a label-free analysis technique that is now widely used to measure the electrical properties of a cell and to differentiate different subpopulations. Current techniques are limited to measuring the impedance of a single cell at one or two simultaneous frequencies. Also, there are no methods that extrapolate the intrinsic electrical properties of single cells. We demonstrate a new approach that uses multifrequency impedance measurements to determine the complete intrinsic electrical properties of thousands of single cells at high throughput. The applicability of the method is demonstrated by measuring the properties of red blood cells and red cell ghosts, deriving the unique values of conductivity and permittivity of the membrane and cytoplasm for each individual cell.
中文翻译：
高速单细胞介电谱。
单细胞阻抗细胞计数法是一种无标记的分析技术，现已广泛用于测量细胞的电特性和区分不同的亚群。当前的技术仅限于在一个或两个同时频率下测量单个电池的阻抗。同样，没有方法可以推断单电池的固有电性能。我们演示了一种新方法，该方法使用多频阻抗测量来确定高吞吐量下数千个单电池的完整固有电学特性。该方法的适用性通过测量红细胞和红细胞重影的性质证明，得出每个单个细胞的膜和细胞质的电导率和介电常数的唯一值。
更新日期：2020-02-17
中文翻译：
高速单细胞介电谱。
单细胞阻抗细胞计数法是一种无标记的分析技术，现已广泛用于测量细胞的电特性和区分不同的亚群。当前的技术仅限于在一个或两个同时频率下测量单个电池的阻抗。同样，没有方法可以推断单电池的固有电性能。我们演示了一种新方法，该方法使用多频阻抗测量来确定高吞吐量下数千个单电池的完整固有电学特性。该方法的适用性通过测量红细胞和红细胞重影的性质证明，得出每个单个细胞的膜和细胞质的电导率和介电常数的唯一值。
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