Early life prevention of obesity and associated metabolic disease is necessary to address the current obesity epidemic. Latino children have a higher risk of obesity, and associated comorbidities such as hypertension than Caucasian children. This study focuses on perinatal childhood and maternal risk factors associated with prehypertension and hypertension prior to age 9 in an urban Latino cohort. A cohort of low income, US born Latino children (n = 131) in San Francisco was followed from birth. Annual assessments were conducted including child dietary intake, anthropometrics, and blood pressure measurements. Maternal body mass index and depressive symptoms were assessed concurrently. Leukocyte telomere length was assessed at age 4 and 5 in children. Rapid infant weight gain (odds ratio (OR) 7.25, 95% confidence interval (CI) 1.33-39.38) and prenatal maternal clinical depression (OR 6.70 95% CI 1.15-39.16) were associated with prehypertension/hypertension before age 9. Early life obesity and leukocyte telomere length were not associated with childhood hypertension. Rapid infant weight gain and exposure to prenatal maternal depression are predictive of childhood prehypertension/hypertension before age 9 in low income, US-born Latino children. The perinatal period is an important time point to target for prevention of childhood hypertension.

中文翻译：

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婴儿体重快速增加和产前母亲抑郁与 9 岁之前的高血压前期/高血压有关。

预防肥胖和相关代谢疾病的早期预防对于解决当前的肥胖流行是必要的。与白人儿童相比，拉丁裔儿童患肥胖症和高血压等相关并发症的风险更高。这项研究的重点是在城市拉丁裔队列中与 9 岁之前的高血压前期和高血压相关的围产期儿童和母亲危险因素。一群在美国出生的低收入、在旧金山出生的拉丁裔儿童（n = 131）从出生开始就被跟踪。进行了年度评估，包括儿童饮食摄入量、人体测量学和血压测量。同时评估母亲的体重指数和抑郁症状。在 4 岁和 5 岁时评估了儿童的白细胞端粒长度。婴儿体重快速增加（优势比 (OR) 7.25，95% 置信区间 (CI) 1.33-39）。38) 和产前母亲临床抑郁症 (OR 6.70 95% CI 1.15-39.16) 与 9 岁之前的高血压前期/高血压相关。早年肥胖和白细胞端粒长度与儿童期高血压无关。婴儿体重快速增加和产前母亲抑郁症是低收入、美国出生的拉丁裔儿童 9 岁前儿童高血压前期/高血压的预测因素。围产期是预防儿童高血压的重要时间点。婴儿体重快速增加和产前母亲抑郁症是低收入、美国出生的拉丁裔儿童 9 岁前儿童高血压前期/高血压的预测因素。围产期是预防儿童高血压的重要时间点。婴儿体重快速增加和产前母亲抑郁症是低收入、美国出生的拉丁裔儿童 9 岁前儿童高血压前期/高血压的预测因素。围产期是预防儿童高血压的重要时间点。