Abstract By using a mixed-ligand approach, a new Co(II)-mediated pyridinium-bearing coordination polymer, {[Co(BCbpe)(ipa)]·3H2O}n (1), has been prepared by reaction of Co(NO3)2·6H2O) and isophthalic acid (H2ipa) in the presence of pyridinium chloride 1-(4-carboxybenzyl)4-[2-(4-pyridyl)-vinyl] (HBCbpeCl) in EtOH/H2O (V:V = 1:1). Furthermore, a green hand grinding technique has been implemented to reduce the particle size of 1 to generate nanosheets of 1 with good water dispersivity. The post-traumatic osteoarthritis (OA) model was constructed and the in vivo protective effect of nano 1 was evaluated. First, the inflammatory level of OA rats was measured by ELISA detection. Second, for further detection, the real-time RT-PCR was carried out to measure the relative expression of caspase-1, nlrp3 as well as il-1β inflammatory factors. Finally, molecular docking analysis of the complex indicated that all of the proposed drug candidates showed desirable drug-like criteria. Graphical Abstract

中文翻译：

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Co(II)介导的含吡啶配位聚合物的晶体结构和对骨关节炎的保护作用

摘要 采用混合配体方法，通过 Co(NO3) 反应制备了一种新的 Co(II) 介导的含吡啶的配位聚合物 {[Co(BCbpe)(ipa)]·3H2O}n (1)。 )2·6H2O) 和间苯二甲酸 (H2ipa) 在氯化吡啶 1-(4-羧基苄基)4-[2-(4-吡啶基)-乙烯基] (HBCbpeCl) 存在下在 EtOH/H2O (V:V = 1 :1)。此外，还实施了绿色手工研磨技术，以减小 1 的粒径，以生成具有良好水分散性的 1 纳米片。构建创伤后骨关节炎（OA）模型并评价nano 1的体内保护作用。首先，通过ELISA检测测量OA大鼠的炎症水平。其次，为了进一步检测，进行实时RT-PCR以测量caspase-1、nlrp3以及il-1β炎症因子的相对表达。最后，该复合物的分子对接分析表明，所有提议的候选药物都显示出理想的类药物标准。图形概要