Abstract A novel red copper(II) compound, bis(μ-bromo)bis(2-(benzothiazol-2-yl-hydrazono)-1,2-diphenyl-ethanone)-dicopper(II) (1), has been fostered by equimolar reaction of a Schiff-base ligand, 2-(benzothiazol-2-yl-hydrazono)-1,2-diphenyl-ethanone (LH), with copper(II) bromide in satisfactory yield. 1 has thoroughly been characterized by C, H and N elemental analyses, FT-IR and UV-vis (both in solid state and in solution) spectroscopies, and room-temperature magnetic susceptibility and conductivity measurements. Dimeric 1 bears symmetric rare bromo-bridges in its crystal structure. 1 retains its solid-state identity even in a protic solvent like methanol. 1 in methanol displays two-step one-electron redox response. Theoretical calculations based on DFT were executed to probe the electronic structure of 1 and to augment its color. DNA- and RNA-binding aspects of both LH and 1 have been explored. Thermodynamic binding parameters have been determined. LH is a major-groove binder to DNA, while 1 manifests itself as a minor-groove binder. This binding has been corroborated through molecular docking. Nucleic acid binding aspect of such type of rare bromo-bridged red copper(II) dimer is unprecedented. Graphical Abstract

中文翻译：

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从希夫碱配体稳定的新型溴桥二聚铜 (II) 复合物的 DNA 和 RNA 结合研究

摘要 一种新型的紫铜（II）化合物，双（μ-溴）双（2-（苯并噻唑-2-基-腙）-1,2-二苯基-乙酮）-二铜（II）（1）被培育出来。通过席夫碱配体 2-(苯并噻唑-2-基-腙)-1,2-二苯基-乙酮 (LH) 与溴化铜 (II) 以令人满意的收率进行等摩尔反应。1 已通过 C、H 和 N 元素分析、FT-IR 和 UV-vis（固态和溶液）光谱以及室温磁化率和电导率测量进行彻底表征。二聚体 1 在其晶体结构中带有对称的稀有溴桥。即使在甲醇等质子溶剂中，1 仍保持其固态特性。1 在甲醇中显示两步单电子氧化还原响应。执行基于 DFT 的理论计算以探测 1 的电子结构并增强其颜色。已经探索了 LH 和 1 的 DNA 和 RNA 结合方面。热力学结合参数已经确定。LH 是 DNA 的大沟结合剂，而 1 则表现为小沟结合剂。这种结合已通过分子对接得到证实。这种罕见的溴桥红铜（II）二聚体的核酸结合方面是前所未有的。图形概要