BACKGROUND Preeclampsia represents a major pregnancy complication, associated with high rates of perinatal morbidity. The aim of this systematic review is to accumulate current literature evidence in order to examine the pattern of serum adipokine levels among preeclamptic women and asses their potential efficacy in the prediction of the disease. METHODS Medline, Scopus, CENTRAL, Clinicaltrials.gov and Google Scholar databases were systematically searched from inception. All observational studies reporting serum adipokine values among preeclamptic and healthy pregnant women were held eligible. RESULTS A total of 163 studies were included, comprising 23,482 women. Leptin was evaluated in 91 studies and its values were found to be significantly elevated in preeclamptic women during all pregnancy trimester, independently of disease onset and severity. Preeclampsia was also associated with increased serum fatty acid binding protein-4 and chemerin levels, when measured both during the 1st and 3rd trimester. Data concerning the rest adipokines were either conflicting or limited to reach firm conclusions. Quality of evidence was evaluated to be high for leptin, moderate for serum fatty acid binding protein-4 and chemerin and low for the other adipokines. CONCLUSIONS The existing evidence suggests that preeclampsia is linked to increased levels of leptin, chemerin and fatty acid binding protein-4 in all pregnancy trimesters and forms of the disease. Inconsistent data currently exists concerning the role of the other adipokines. Large-scale prospective studies should longitudinally evaluate the serum concentration of novel adipokines and define the optimal threshold and timing of measurement to be widely applied in clinical practice.

中文翻译：

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血清脂肪因子水平在先兆子痫中的作用：系统评价。

背景技术子痫前期代表主要的妊娠并发症，与围生期发病率高相关。本系统综述的目的是积累当前的文献证据，以检查先兆子痫妇女的血清脂肪因子水平模式，并评估其在疾病预测中的潜在功效。方法从开始就系统地搜索Medline，Scopus，CENTRAL，Clinicaltrials.gov和Google Scholar数据库。所有报道子痫前期和健康孕妇血清脂肪因子值的观察性研究均符合条件。结果共纳入163项研究，包括23482名女性。在91项研究中对瘦素进行了评估，发现在整个妊娠中期，先兆子痫妇女的瘦素水平均显着升高，与疾病的发作和严重程度无关。当在妊娠的第三个和第三个妊娠期进行测量时，子痫前期还与血清脂肪酸结合蛋白4和凯莫瑞水平升高有关。有关其余脂肪因子的数据相互矛盾或仅限于得出明确的结论。评估的证据质量是：瘦素高，血清脂肪酸结合蛋白4和凯莫瑞中等，其他脂肪因子低。结论现有证据表明，子痫前期与所有妊娠中期和疾病形式的瘦素，凯莫瑞和脂肪酸结合蛋白4水平升高有关。当前关于其他脂肪因子的作用存在不一致的数据。