Helicobacter pylori colonizes human stomach mucosa and its infection causes gastrointestinal diseases with variable severity. Bacterial infection stimulates autophagy, which is a part of innate immunity used to eliminate intracellular pathogens. Several intracellular bacteria have evolved multipronged strategies to circumvent this conserved system and thereby enhance their chance of intracellular survival. Nonetheless, studies on H. pylori have produced inconsistent results, showing either elevated or reduced clearance efficiency of intracellular bacteria through autophagy. In this review, we summarize recent studies on the mechanisms involved in autophagy induced by H. pylori and the fate of intracellular bacteria.

中文翻译：

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幽门螺杆菌在规避其细胞内命运方面的细胞逃避策略。

幽门螺杆菌定居在人的胃粘膜上，其感染导致严重程度不同的胃肠道疾病。细菌感染会刺激自噬，这是用于消除细胞内病原体的先天免疫力的一部分。几种细胞内细菌已经进化出多管齐下的策略来规避这个保守的系统，从而增加其细胞内存活的机会。然而，关于幽门螺杆菌的研究产生不一致的结果，表明通过自噬使细胞内细菌的清除效率升高或降低。在这篇综述中，我们总结了有关幽门螺杆菌诱导的自噬和细胞内细菌命运的最新研究。