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The interrelationship between physical activity and metabolic regulation of breast cancer progression in obesity via cytokine control.
Cytokine & Growth Factor Reviews ( IF 9.3 ) Pub Date : 2020-02-04 , DOI: 10.1016/j.cytogfr.2020.02.001 Delphine Le Guennec 1 , Adrien Rossary 1
Cytokine & Growth Factor Reviews ( IF 9.3 ) Pub Date : 2020-02-04 , DOI: 10.1016/j.cytogfr.2020.02.001 Delphine Le Guennec 1 , Adrien Rossary 1
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Regular physical activity is known to protect against the development of breast cancer and mediate direct anti-inflammatory effects on adipose tissue. While direct relationships between muscle activity, adipose tissue and breast tissue have been highlighted in recent years, few studies have focused on the effects of obesity and physical activity during the development of breast cancer, particularly at the level of cell signaling. Skeletal muscle and adipose tissue modulate the cell metabolism by secreting myokines and adipokines. These secreted cytokines belong to a crosstalk network via cell signaling pathway modulation. The understanding of the tissue crosstalk is fundamental to the management of physical activity in the care of obese breast cancer patients. Therefore, this review focuses on the effects of obesity and physical activity during the development of breast cancer, particularly at the level of cell signaling. We focuse on the main mediators, secreted by both adipose and muscle tissue, which are implicated in breast cancer development. We presente the variation of these mediators in the physiopathological context of their secreted tissue. Then, we open the discussion on the crosstalk of these tissues in breast carcinogenesis.
中文翻译：
身体活动与肥胖通过细胞因子控制在肥胖中进展的代谢调节之间的相互关系。
已知定期进行体育锻炼可以预防乳腺癌的发展并介导对脂肪组织的直接消炎作用。尽管近年来肌肉活动，脂肪组织和乳房组织之间的直接关系得到了强调，但是很少有研究集中于肥胖和身体活动在乳腺癌发展过程中的影响，特别是在细胞信号传导方面。骨骼肌和脂肪组织通过分泌肌动蛋白和脂肪因子来调节细胞代谢。这些分泌的细胞因子通过细胞信号传导途径的调节属于串扰网络。对组织串扰的理解是肥胖乳癌患者护理中体育锻炼管理的基础。因此，这篇综述着重于肥胖症和身体活动在乳腺癌发展过程中的影响，特别是在细胞信号传导方面。我们专注于脂肪和肌肉组织分泌的主要介体，它们与乳腺癌的发展有关。我们介绍了这些介质在其分泌组织的生理病理学背景下的变异。然后，我们开始讨论这些组织在乳癌中的串扰。
更新日期：2020-02-04
中文翻译：
身体活动与肥胖通过细胞因子控制在肥胖中进展的代谢调节之间的相互关系。
已知定期进行体育锻炼可以预防乳腺癌的发展并介导对脂肪组织的直接消炎作用。尽管近年来肌肉活动，脂肪组织和乳房组织之间的直接关系得到了强调，但是很少有研究集中于肥胖和身体活动在乳腺癌发展过程中的影响，特别是在细胞信号传导方面。骨骼肌和脂肪组织通过分泌肌动蛋白和脂肪因子来调节细胞代谢。这些分泌的细胞因子通过细胞信号传导途径的调节属于串扰网络。对组织串扰的理解是肥胖乳癌患者护理中体育锻炼管理的基础。因此，这篇综述着重于肥胖症和身体活动在乳腺癌发展过程中的影响，特别是在细胞信号传导方面。我们专注于脂肪和肌肉组织分泌的主要介体，它们与乳腺癌的发展有关。我们介绍了这些介质在其分泌组织的生理病理学背景下的变异。然后，我们开始讨论这些组织在乳癌中的串扰。
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