The dynamics of memory processes are conserved throughout evolution, a feature based on the hypothesis of a common origin of the high-order memory centers in bilateral animals. Reconsolidation is just one example. The possibility to interfere with long-term memory expression during reconsolidation has been proposed as potentially useful in clinical application to treat traumatic memories. However, several pieces of evidence in rodents show that either robust fear memories or stressful events applied before acquisition promote reconsolidation-resistant memories, i.e., memories that are resistant to the interfering effect of drugs on memory reconsolidation. Conceivably, the generation of these reconsolidation-resistant fear memories also occurs in humans. Is the induction of reconsolidation-resistant memories part of the dynamics of memory processes conserved throughout evolution? In the semiterrestrial crab Neohelice granulata, memory reconsolidation is triggered by a short reminder without reinforcement. Here, we show that an increase in the salience of the aversive stimulus augmented the memory strength; nonetheless, the protein synthesis inhibitor cycloheximide still disrupted the reconsolidation process. However, crabs stressed by a water-deprivation episode before a strong training session built up a memory that was now reconsolidation-resistant. We tested whether these reconsolidation-resistant effects can be challenged by changing parametric conditions of memory-reminder sessions; multiple memory reactivations without reinforcement were not able to trigger the labilization-reconsolidation of this resistant memory. Overall, the present findings suggest that generation of reconsolidation-resistant memories can be another part of the dynamics of memory processes conserved throughout evolution that protects privileged information from change.

中文翻译：

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与压力源一起建立的记忆是特权：螃蟹 Neohelice 中的抗再巩固记忆。

记忆过程的动力学在整个进化过程中是保守的，这一特征基于双侧动物高阶记忆中心的共同起源假设。重组只是一个例子。已经提出在再巩固过程中干扰长期记忆表达的可能性在治疗创伤性记忆的临床应用中可能有用。然而，啮齿类动物的一些证据表明，在获得之前施加的强大的恐惧记忆或压力事件会促进抗再巩固记忆，即对药物对记忆再巩固的干扰作用有抵抗力的记忆。可以想象，这些抗再巩固恐惧记忆的产生也发生在人类身上。抗再巩固记忆的诱导是整个进化过程中保存的记忆过程动力学的一部分吗？在半陆蟹 Neohelice granulata 中，记忆再巩固是由没有强化的短暂提醒触发的。在这里，我们表明厌恶刺激显着性的增加增强了记忆强度；尽管如此，蛋白质合成抑制剂放线菌酮仍然扰乱了再巩固过程。然而，在强烈的训练课程之前因缺水事件而感到压力的螃蟹建立了一种现在可以抵抗再巩固的记忆。我们测试了是否可以通过改变记忆提醒会话的参数条件来挑战这些抗再巩固效应；没有强化的多次记忆重新激活无法触发这种抗性记忆的不稳定化-再巩固。总的来说，目前的研究结果表明，抗再巩固记忆的产生可能是整个进化过程中保存的记忆过程动态的另一部分，保护特权信息免受变化。