Modern genome analysis and phylogenomic methods have increased the number of fungal species, as well as enhanced appreciation of the degree of diversity within the fungal kingdom. In this context, we describe a new Parengyodontium species, P. americanum, which is phylogenetically related to the opportunistic human fungal pathogen P. album. Five unusual fungal isolates were recovered from five unique and confirmed coccidioidomycosis patients, and these isolates were subsequently submitted to detailed molecular and morphological identification procedures to determine identity. Molecular and morphological diagnostic analyses showed that the isolates belong to the Cordycipitaceae. Subsequently, three representative genomes were sequenced and annotated, and a new species, P. americanum, was identified. Using various genomic analyses, gene family expansions related to novel compounds and potential for ability to grow in diverse habitats are predicted. A general description of the genomic composition of this newly described species and comparison of genome content with Beauveria bassiana, Isaria fumosorosea and Cordyceps militaris shows a shared core genome of 6371 genes, and 148 genes that appear to be specific for P. americanum. This work provides the framework for future investigations of this interesting fungal species.

中文翻译：

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Parengyodontium americanum sp。的基因组表征。十一月

现代基因组分析和系统生物学方法已经增加了真菌种类的数量，并增强了对真菌界内多样性程度的认识。在这种情况下，我们描述了一种新的Parengyodontium物种，美洲种，这与机会性人类真菌病原体P.专辑在系统发育上相关。从五名独特且确诊的球孢菌病患者中回收了五种不寻常的真菌分离物，随后将这些分离物进行详细的分子和形态学鉴定程序以确定身份。分子和形态学诊断分析表明，分离物属于虫草科。随后，对三个代表性基因组进行了测序和注释，并鉴定了一个新物种，美洲假单胞菌。使用各种基因组分析，可以预测与新化合物相关的基因家族扩展以及在不同栖息地中生长的潜力。对该新近描述物种的基因组组成进行一般描述，并与球孢白僵菌，深海伊萨里亚和and虫草的基因组含量进行比较，显示共有6371个基因和148个似乎对美洲假单胞菌具有特异性的核心基因组。这项工作为今后研究这种有趣的真菌物种提供了框架。148个似乎对美洲假单胞菌具有特异性的基因。这项工作为今后研究这种有趣的真菌物种提供了框架。148个似乎对美洲假单胞菌具有特异性的基因。这项工作为今后研究这种有趣的真菌物种提供了框架。