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Limited joint mobility of the hand correlates incident hospitalisation with infection in patients with type 2 diabetes.
Diabetes Research and Clinical Practice ( IF 6.1 ) Pub Date : 2020-02-01 , DOI: 10.1016/j.diabres.2020.108049
Yusuke Mineoka 1 , Michiyo Ishii 1 , Yoshitaka Hashimoto 2 , Shinnosuke Hata 2 , Hiroyuki Tominaga 1 , Naoto Nakamura 3 , Yasukazu Katsumi 4 , Michiaki Fukui 2
Affiliation  

AIM Limited joint mobility (LJM) of the hand is one of the important complications of diabetes. Diabetes is a risk factor for hospitalisation with infection. This study investigated the relationship between LJM of the hand and the incidence of hospitalisation with infection in type 2 diabetic patients. MATERIALS AND METHODS LJM of hand was defined as the 'prayer sign' or 'table test'. The association between LJM of the hand and incident hospitalisations was evaluated using Cox regression analysis. The number of incident hospitalisations was small over the course of the study, which we compensated for by calculating propensity scores using age, body mass index, sex, duration of diabetes, creatinine, smoking status, haemoglobin A1c and dyslipidaemia. RESULTS In this retrospective cohort study of 502 patients with type 2 diabetes, 102 patients had LJM of the hand. These patients were, on average, older and had worse renal function and glycaemic control, and a higher proportion of microangiopathy significantly. During the study period, 56 patients were hospitalised with infection. A Cox regression analysis showed that LJM of the hand was associated with an increased probability of incident hospitalisation with infection after adjustment for covariates (HR = 1.65 [95% CI 1.60-1.70], p < 0.001). CONCLUSIONS Our results reveal that LJM of the hand is associated with incident of hospitalisation with infection. A diagnosis of LJM of the hand might, therefore, be a useful indicator for assessing the risk of hospitalisation with infection in type 2 diabetic patients.

中文翻译:

手部关节活动受限使2型糖尿病患者的事件住院治疗与感染相关。

AIM手的关节活动受限(LJM)是糖尿病的重要并发症之一。糖尿病是感染住院的危险因素。本研究调查了2型糖尿病患者手部LJM与感染住院率之间的关系。材料与方法手的LJM被定义为“祷告标志”或“餐桌测试”。使用Cox回归分析评估手的LJM与住院事件之间的关联。在整个研究过程中,住院事件的数量很少,我们通过使用年龄,体重指数,性别,糖尿病持续时间,肌酐,吸烟状况,血红蛋白A1c和血脂异常来计算倾向得分来弥补这一不足。结果在这项回顾性队列研究中,对502例2型糖尿病患者进行了研究,102例患者患有手部LJM。这些患者平均年龄较大,肾功能和血糖控制较差,且微血管病变比例明显较高。在研究期间,有56名患者被感染住院。Cox回归分析表明,调整协变量后,手部LJM与感染住院的可能性增加相关(HR = 1.65 [95%CI 1.60-1.70],p <0.001)。结论我们的结果表明,手的LJM与感染住院有关。因此,手部LJM的诊断可能是评估2型糖尿病患者因感染而住院的风险的有用指标。年龄较大,肾功能和血糖控制较差,微血管病变比例明显升高。在研究期间,有56名患者被感染住院。Cox回归分析表明,调整协变量后,手部LJM与感染住院的可能性增加相关(HR = 1.65 [95%CI 1.60-1.70],p <0.001)。结论我们的结果表明,手的LJM与感染住院有关。因此,手部LJM的诊断可能是评估2型糖尿病患者因感染而住院的风险的有用指标。年龄较大,肾功能和血糖控制较差,微血管病变比例明显升高。在研究期间,有56名患者被感染住院。Cox回归分析表明,调整协变量后,手部LJM与感染住院的可能性增加相关(HR = 1.65 [95%CI 1.60-1.70],p <0.001)。结论我们的结果表明,手的LJM与感染住院有关。因此,手部LJM的诊断可能是评估2型糖尿病患者因感染而住院的风险的有用指标。Cox回归分析表明,调整协变量后,手部LJM与感染住院的可能性增加相关(HR = 1.65 [95%CI 1.60-1.70],p <0.001)。结论我们的结果表明,手的LJM与感染住院有关。因此,手部LJM的诊断可能是评估2型糖尿病患者因感染而住院的风险的有用指标。Cox回归分析表明,调整协变量后,手部LJM与感染住院的可能性增加相关(HR = 1.65 [95%CI 1.60-1.70],p <0.001)。结论我们的结果表明,手的LJM与感染住院有关。因此,手部LJM的诊断可能是评估2型糖尿病患者因感染而住院的风险的有用指标。
更新日期:2020-02-03
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