Supplemental Digital Content is available in the text. The recommendations for the diagnosis of stage 1 hypertension were recently revised by the American Heart Association primarily based on its impact on cardiovascular disease risks. Whether the newly diagnosed stage 1 hypertension impacts pregnancy complications remain poorly defined. We designed a retrospective cohort study to investigate the associations of stage 1 hypertension detected in early gestation (<20 weeks) with risks of adverse pregnancy outcomes stratified by prepregnancy body mass index. A total of 47 874 women with singleton live births and blood pressure (BP) <140/90 mm Hg were included, with 5781 identified as stage 1a (systolic BP, 130–134 mm Hg; diastolic BP, 80–84 mm Hg; or both) and 3267 as stage 1b hypertension (systolic BP, 135–139 mm Hg; diastolic BP, 85–90 mm Hg; or both). Slightly higher, yet significant, rates and risks of gestational diabetes mellitus, preterm delivery, and low birth weight (<2500 g) were observed in both groups compared with normotensive controls. Importantly, women with stage 1a and stage 1b hypertension had significantly increased incidences of hypertensive disorders in pregnancy compared with normotensive women (adjusted odds ratio, 2.34 [95% CI, 2.16–2.53]; 3.05 [2.78–3.34], respectively). After stratifying by body mass index, stage 1a and 1b hypertension were associated with increased hypertensive disorders in pregnancy risks in both normal weight (body mass index, 18.5–24.9; adjusted odds ratio, 2.44 [2.23–2.67]; 3.26 [2.93–3.63]) and the overweight/obese (body mass index, ≥25; adjusted odds ratio, 1.90 [1.56–2.31]; 2.36 [1.92–2.90]). Current findings suggested significantly increased adverse pregnancy outcomes associated with stage 1 hypertension based on the revised American Heart Association guidelines, especially in women with prepregnancy normal weight.

中文翻译：

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低风险队列中与 1 期高血压相关的不良妊娠结局增加

补充数字内容在文本中可用。美国心脏协会最近修订了 1 期高血压诊断的建议，主要是基于其对心血管疾病风险的影响。新诊断的 1 期高血压是否会影响妊娠并发症仍不清楚。我们设计了一项回顾性队列研究，以调查在妊娠早期（<20 周）检测到的 1 期高血压与按孕前体重指数分层的不良妊娠结局风险之间的关联。共有 47 874 名单胎活产且血压 (BP) <140/90 mmHg 的妇女被纳入，其中 5781 名被确定为 1a 期（收缩压，130-134 mmHg；舒张压，80-84 mmHg；或两者）和 3267 作为 1b 期高血压（收缩压，135-139 毫米汞柱；舒张压，85-90 毫米汞柱；或两者）。与血压正常的对照组相比，两组的妊娠期糖尿病、早产和低出生体重 (<2500 g) 的发生率和风险均略高但显着。重要的是，与血压正常的女性相比，患有 1a 期和 1b 期高血压的女性妊娠期高血压疾病的发生率显着增加（调整后的优势比分别为 2.34 [95% CI，2.16-2.53]；3.05 [2.78-3.34]）。按体重指数分层后，1a 期和 1b 期高血压与正常体重（体重指数，18.5–24.9；调整后的优势比，2.44 [2.23–2.67]；3.26 [2.93–3.63] ]) 和超重/肥胖（体重指数，≥25；调整优势比，1.90 [1.56–2.31]；2.36 [1.92–2.90]）。