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Multi-dimensional electrical impedance myography of the tongue as a potential biomarker for amyotrophic lateral sclerosis
Clinical Neurophysiology ( IF 3.7 ) Pub Date : 2020-04-01 , DOI: 10.1016/j.clinph.2019.12.418
James J P Alix 1 , Harry E McDonough 2 , Buket Sonbas 3 , Sophie J French 2 , D Ganesh Rao 4 , Visakan Kadirkamanathan 3 , Christopher J McDermott 5 , T Jamie Healey 6 , Pamela J Shaw 5
Affiliation  

OBJECTIVE In amyotrophic lateral sclerosis (ALS) bulbar disease biomarkers are lacking. We evaluated a novel tongue electrical impedance myography (EIM) system, utilising both 2D and 3D electrode configurations for detection of tongue pathology. METHODS Longitudinal multi-frequency phase angle spectra were recorded from 41 patients with ALS (baseline, 3 and 6 months) and 30 healthy volunteers (baseline and 6 months). ALS functional rating scale-revised (ALSFRS-R) data and quantitative tongue strength measurements were collected. EIM data were analysed for reliability (intra-class correlation coefficient; ICC) and differences between patients and volunteers ascertained using both univariate (Mann-Whitney U test) and multivariate techniques (feature selection and L2 norm). RESULTS The device produced highly reliable data (pooled ICC: 0.836). Significant EIM differences were apparent between ALS patients and healthy volunteers (P < 0.001). EIM data demonstrated a significant relationship to tongue strength and bulbar ALSFRS-R scores (P < 0.015). The EIM recordings revealed a group level longitudinal change over 6 months and consistently identified patients in whom symptoms or tongue strength changed. CONCLUSIONS The novel EIM tongue system produces reliable data and can differentiate between healthy muscle and ALS-related disease. SIGNIFICANCE Tongue EIM utilising multiple frequencies and electrode configurations has potential as a bulbar disease biomarker in ALS.

中文翻译:

舌的多维电阻抗肌成像作为肌萎缩侧索硬化的潜在生物标志物

目的 在肌萎缩侧索硬化 (ALS) 中,缺乏延髓疾病的生物标志物。我们评估了一种新颖的舌电阻抗肌成像 (EIM) 系统,该系统利用 2D 和 3D 电极配置来检测舌病理。方法记录了 41 名 ALS 患者(基线、3 个月和 6 个月)和 30 名健康志愿者(基线和 6 个月)的纵向多频相位角谱。收集了 ALS 功能评定量表修订版 (ALSFRS-R) 数据和定量舌头强度测量值。使用单变量(Mann-Whitney U 检验)和多变量技术(特征选择和 L2 范数)分析 EIM 数据的可靠性(类内相关系数;ICC)和确定的患者和志愿者之间的差异。结果 该设备产生高度可靠的数据(汇集 ICC:0.836)。ALS 患者和健康志愿者之间存在显着的 EIM 差异(P < 0.001)。EIM 数据表明舌强度和延髓 ALSFRS-R 评分显着相关(P < 0.015)。EIM 记录显示了 6 个月内组水平的纵向变化,并始终如一地识别出症状或舌头强度发生变化的患者。结论 新的 EIM 舌头系统产生可靠的数据,可以区分健康肌肉和 ALS 相关疾病。意义 利用多个频率和电极配置的舌头 EIM 具有作为 ALS 延髓疾病生物标志物的潜力。EIM 记录显示了 6 个月内组水平的纵向变化,并始终如一地识别出症状或舌头强度发生变化的患者。结论 新的 EIM 舌头系统产生可靠的数据,可以区分健康肌肉和 ALS 相关疾病。意义 舌 EIM 利用多个频率和电极配置具有作为 ALS 延髓疾病生物标志物的潜力。EIM 记录显示了 6 个月内组水平的纵向变化,并始终如一地识别出症状或舌头强度发生变化的患者。结论 新的 EIM 舌头系统产生可靠的数据,可以区分健康肌肉和 ALS 相关疾病。意义 舌 EIM 利用多个频率和电极配置具有作为 ALS 延髓疾病生物标志物的潜力。
更新日期:2020-04-01
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