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Macrophages Instruct Aberrant Glycosylation in Colon Cancer by Chemokine and Cytokine Signals.
Cancer Immunology Research ( IF 8.1 ) Pub Date : 2020-02-01 , DOI: 10.1158/2326-6066.cir-19-1005
Vincenzo Bronte 1
Affiliation  

Myeloid cells can alter diverse molecular and metabolic pathways in cancer cells, contributing to their survival, migration, and resistance to chemotherapy and immune attack. The results by Kvorjak and colleagues unveil a novel circuit whereby altered glycosylation in epithelial cells promotes the pathogenesis of ulcerative colitis and colitis-associated colon cancer, via the production of IL13 and CCL17 by M2-polarized macrophages.See article by Kvorjak et al., p. 167.

中文翻译:

巨噬细胞通过趋化因子和细胞因子信号指导结肠癌中异常糖基化。

髓样细胞可以改变癌细胞中的多种分子和代谢途径,有助于它们的存活,迁移以及对化学疗法和免疫攻击的抵抗力。Kvorjak及其同事的研究结果揭示了一种新的途径,即上皮细胞中糖基化的改变通过M2极化巨噬细胞产生IL13和CCL17促进溃疡性结肠炎和结肠炎相关结肠癌的发病机理。参见Kvorjak等人的文章, p。167。
更新日期:2020-02-03
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