Zika Virus (ZIKV) is a Flavivirus transmitted primarily via the bite of infected Aedes aegypti mosquitoes. Globally, 87 countries and territories have recorded autochthonous mosquito-borne transmission of ZIKV as at July 2019 and distributed across four of the six WHO Regions. Outbreaks of ZIKV infection peaked in 2016 and declined substantially throughout 2017 and 2018 in the Americas region. There is the likely risk for ZIKV to spread to more countries. There is also the potential for the re-emergence of ZIKV in all places with prior reports of the virus transmission. The current status of ZIKV transmission and spread is, however, a global health threat, and from the aforementioned, has the potential to re-emerge as an epidemic. This review summarizes the past and present spread of ZIKV outbreak-2007-2019, the genome, transmission cycle, clinical manifestations, vaccine and antiviral drug advancement.

中文翻译：

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寨卡病毒的传播，流行病学，基因组，传播周期，临床表现，相关挑战，疫苗和抗病毒药物的开发。

寨卡病毒（ZIKV）是一种黄病毒，主要通过被感染的埃及伊蚊（Aedes aegypti）蚊子叮咬传播。截至2019年7月，全球有87个国家和地区记录了ZIKV的土生虫媒传播，并分布在WHO六个区域中的四个区域中。ZIKV感染的爆发在2016年达到顶峰，在美洲地区的整个2017年和2018年大幅下降。ZIKV可能会传播到更多国家。先前有关于病毒传播的报道，ZIKV还有可能在所有地方重新出现。然而，ZIKV传播和传播的当前状况是全球健康威胁，从上述情况来看，ZIKV有可能再次流行。这篇综述总结了2007-2019年ZIKV爆发的过去和现在的传播，基因组，传播周期，