The widely recognized problems of pharmacological strategies based on killing cancer cells demand a rethink of therapeutic approaches. Tumor reversion strategies that aim to shift cancer cells to a healthy differentiated state are a promising alternative. Although many studies have firmly demonstrated the possibility of reverting cancer to a normal differentiated state, we are still unable (with the exception of retinoic acid in a form of leukemia) to revert cancer cells to a stable differentiated healthy state. Here, we review the main biological bases of redifferentiation strategies and provide a description of the most promising research avenues.

中文翻译：

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癌症中的再分化治疗策略。

基于杀死癌细胞的药理策略的广泛认可的问题需要对治疗方法进行重新思考。旨在将癌细胞转变为健康分化状态的肿瘤逆转策略是一种有前途的选择。尽管许多研究已经坚定地证明了将癌症恢复为正常分化状态的可能性，但我们仍然无法（以白血病形式的视黄酸除外）将癌细胞恢复为稳定的分化健康状态。在这里，我们审查了再分化策略的主要生物学基础，并提供了最有前途的研究途径的描述。