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EGFR antibodies in resectable metastatic colorectal liver metastasis: more harm than benefit?
The Lancet Oncology ( IF 41.6 ) Pub Date : 2020-01-31 , DOI: 10.1016/s1470-2045(20)30003-6
Sepideh Gholami 1 , Axel Grothey 2
Affiliation  

The current standard of care for resectable liver-limited colorectal cancer is perioperative chemotherapy followed by curative resection, based on the EORTC trial, which showed a modest improvement in 3-year progression-free survival. Since the addition of a biological agent to systemic therapy leads to increased proportions of patients achieving a response in the metastatic setting, a logical subsequent trial would investigate the role of biological agents in the perioperative setting.

中文翻译:

可切除的转移性结直肠肝转移中的EGFR抗体:弊大于利?

根据EORTC试验,可切除的肝脏受限的结直肠癌的当前护理标准是围手术期化疗,然后进行根治性切除,该试验显示3年无进展生存率有一定程度的改善。由于在全身性治疗中添加生物制剂会导致在转移性环境中获得缓解的患者比例增加,因此,一项合理的后续试验将研究生物制剂在围手术期中的作用。
更新日期:2020-03-03
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