Promiscuous Ribozymes and Their Proposed Role in Prebiotic Evolution.,Chemical Reviews

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Promiscuous Ribozymes and Their Proposed Role in Prebiotic Evolution.
Chemical Reviews ( IF 51.4 ) Pub Date : 2020-02-03 , DOI: 10.1021/acs.chemrev.9b00620
Evan Janzen _{1,

2} , Celia Blanco ₁ , Huan Peng ₁ , Josh Kenchel _{1,

2} , Irene A Chen _{1,

2,

3}

Affiliation

The ability of enzymes, including ribozymes, to catalyze side reactions is believed to be essential to the evolution of novel biochemical activities. It has been speculated that the earliest ribozymes, whose emergence marked the origin of life, were low in activity but high in promiscuity, and that these early ribozymes gave rise to specialized descendants with higher activity and specificity. Here, we review the concepts related to promiscuity and examine several cases of highly promiscuous ribozymes. We consider the evidence bearing on the question of whether de novo ribozymes would be quantitatively more promiscuous than later evolved ribozymes or protein enzymes. We suggest that while de novo ribozymes appear to be promiscuous in general, they are not obviously more promiscuous than more highly evolved or active sequences. Promiscuity is a trait whose value would depend on selective pressures, even during prebiotic evolution.

中文翻译：

混杂的核酶及其在益生元进化中的作用。

酶（包括核酶）催化副反应的能力被认为对新型生化活性的发展至关重要。据推测，最早出现的核酶（其出现标志着生命的起源）活动度低而滥交性高，这些早期的核酶产生了具有更高活性和特异性的专门后代。在这里，我们回顾了与滥交有关的概念，并研究了几例高度混杂的核酶。我们认为有关从头核酶是否比以后进化的核酶或蛋白质酶在数量上更混杂的问题的证据。我们建议您从头开始核酶一般看起来是混杂的，它们显然不比进化或活性更高的序列混杂。滥交是一种特征，即使在益生元进化过程中，其价值也取决于选择性压力。

更新日期：2020-02-03

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