This study analyzes and evaluates the use of cellulose nanocrystals (CNCs), stiff nanosized natural materials that have been modified to mimic heparin. These CNCs are simple polysaccharides with a similar backbone structure to heparin, which when modified reduces coagulation and potentially the long-term effects of solution-based anticoagulants. Thus, CNCs represent an ideal foundation for generating materials biocompatible with blood. In this study, we developed a biocompatible material that inhibits blood clotting through surface functionalization to mimic heparin. Surface chemistry of CNCs was modified from "plain" CNCs (70 mmol SO3-/kg) to 500 mmol COO-/kg (TEMPO-oxidized CNCs) and 330 mmol SO3-/kg CNCs (sulfonated CNCs). Platelet adherence and blood assays show that changes in functionalization reduce coagulation. By utilizing and modifying CNCs reactive functional groups, we create a material with unique and favorable mechanical properties while also reducing clotting.

中文翻译：

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源自纤维素纳米晶体的肝素模拟物质。

这项研究分析和评估了纤维素纳米晶体（CNC）的用途，纤维素纳米晶体是经过硬质改性的纳米级天然材料，可模仿肝素。这些CNCs是具有与肝素相似的主链结构的简单多糖，经修饰可减少凝血，并降低基于溶液的抗凝剂的长期作用。因此，CNCs是产生与血液生物相容的材料的理想基础。在这项研究中，我们开发了一种生物相容性材料，该材料可通过表面功能化模仿肝素来抑制血液凝结。CNCs的表面化学从“普通” CNCs（70 mmol SO3- / kg）修改为500 mmol COO- / kg（TEMPO氧化的CNCs）和330 mmol SO3- / kg CNCs（磺化CNCs）。血小板粘附和血液测定表明功能性的改变减少了凝血。