A first analysis of simultaneous ⁶⁸Ga-prostate-specific membrane antigen (PSMA)-11 PET/MRI showed some improvement in the detection of recurrent disease at low serum prostate specific antigen (PSA) values below 0.5 ng/mL compared with the already high detection rate of ⁶⁸Ga-PSMA-11 PET/CT. We therefore focused on all patients with biochemical recurrence and PSA values no higher than 0.5 ng/mL to assess the detection rate for ⁶⁸Ga-PSMA-11 PET/MRI. Methods: We retrospectively analyzed a cohort of 66 consecutive patients who underwent ⁶⁸Ga-PSMA-11 PET/MRI for biochemical recurrence with a PSA value no higher than 0.5 ng/mL at our institution. Median PSA level was 0.23 ng/mL (range, 0.03–0.5 ng/mL). Detection of PSMA-positive lesions within the prostate fossa, local and distant lymph nodes, bones, or visceral organs was recorded. In addition, all scans with ⁶⁸Ga-PSMA-11 PET/MRI–positive lesions were retrospectively assessed to analyze if lesions were detected inside or outside a standard salvage radiotherapy volume. Results: Overall, in 36 of 66 patients (54.5%) PSMA-positive lesions were detected; in 26 of 40 (65%) patients with a PSA level between 0.2 and 0.5 ng/mL and in 10 of 26 (38.5%) patients with a PSA level less than 0.2 ng/mL. Even at those low PSA values, only 8 of 66 (12.1%) patients had exclusive local recurrence. Lymph nodes were detected in 23 patients and bone metastases in 5 on ⁶⁸Ga-PSMA-11 PET/MRI. In 26 of 66 patients (39.4%), PSMA-positive lesions were located outside a standard salvage radiotherapy volume. Conclusion: Our data confirm that ⁶⁸Ga-PSMA-11 PET/MRI has a high detection rate for recurrent prostate cancer, even at low PSA levels no higher than 0.5 ng/mL. In addition, we show that ⁶⁸Ga-PSMA-11 PET/MRI detected PSMA-positive lesions outside a standard salvage radiotherapy volume in 39.4% of all patients.

对同时进行的⁶⁸ Ga-前列腺特异性膜抗原（PSMA）-11 PET / MRI的首次分析显示，与已经很高的血清前列腺特异性抗原（PSA）值相比，低于0.5 ng / mL的低血清前列腺特异性抗原（PSA）值，对复发性疾病的检测有所改善检出率为⁶⁸ Ga-PSMA-11 PET / CT。因此，我们重点研究了所有生化复发且PSA值不高于0.5 ng / mL的患者，以评估⁶⁸ Ga-PSMA-11 PET / MRI的检出率。方法：我们回顾性分析了66例连续患者，其中⁶⁸例Ga-PSMA-11 PET / MRI用于我院的生化复发，PSA值不高于0.5 ng / mL。PSA中位数为0.23 ng / mL（范围0.03-0.5 ng / mL）。记录了前列腺窝，局部和远处淋巴结，骨骼或内脏器官内PSMA阳性病变的检测。此外，回顾性评估了所有⁶⁸ Ga-PSMA-11 PET / MRI阳性病变的扫描结果，以分析是否在标准抢救放疗量之内或之外检测到病变。结果：总体而言，在66例患者中，有36例（54.5％）检出了PSMA阳性病变。PSA水平在0.2到0.5 ng / mL之间的40名患者中有26名（65％），PSA水平低于0.2 ng / mL的26名患者中有10名（38.5％）。即使在那些较低的PSA值下，在66名患者中只有8名（12.1％）仅有局部复发。⁶⁸ Ga-PSMA-11 PET / MRI检出23例患者的淋巴结，检出5例骨转移。在66例患者中的26例（占39.4％）中，PSMA阳性病变位于标准抢救放疗范围之外。结论：我们的数据证实，即使在PSA水平不高于0.5 ng / mL的情况下，⁶⁸ Ga-PSMA-11 PET / MRI对复发性前列腺癌的检测率也很高。另外，我们表明⁶⁸Ga-PSMA-11 PET / MRI在所有患者的39.4％的标准抢救放疗量之外检测到PSMA阳性病变。