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Tumor-to-Blood Ratio for Assessment of Somatostatin Receptor Density in Neuroendocrine Tumors Using 68Ga-DOTATOC and 68Ga-DOTATATE
The Journal of Nuclear Medicine ( IF 9.1 ) Pub Date : 2020-02-01 , DOI: 10.2967/jnumed.119.228072
Ezgi Ilan , Irina Velikyan , Mattias Sandström , Anders Sundin , Mark Lubberink

PET/CT with 68Ga-DOTA-somatostatin analogs has been tested for therapy monitoring in patients with neuroendocrine tumors (NETs). However, SUVs in tumors do not correlate with the net influx rate (Ki), as a representation of the somatostatin receptor expression. In this study, tumor-to-blood ratio (TBR) was evaluated as an alternative tool for semiquantitative assessment of 68Ga-DOTATOC and 68Ga-DOTATATE tumor uptake and as a therapy monitoring tool for patients with NETs. Methods: Twenty-two NET patients underwent a 45-min dynamic PET/CT scan after injection of 68Ga-DOTATOC or 68Ga-DOTATATE. Ki was determined using the Patlak method, and TBR was calculated for the 40- to 45-min interval. Results: A linear relation was found between Ki and TBR, with a square of Pearson correlation of 0.98 and 0.93 for 68Ga-DOTATOC and 68Ga-DOTATATE, respectively. Conclusion: A high correlation was found between Ki and TBR. Hence, TBR reflects somatostatin receptor density more accurately than SUV and is suggested as the preferred metric for semiquantitative assessment of 68Ga-DOTATOC and 68Ga-DOTATATE tumor uptake.



中文翻译:

使用68 Ga-DOTATOC和68 Ga- DOTATATE评估神经内分泌肿瘤中生长抑素受体密度的肿瘤血比

PET / CT和68 Ga-DOTA-生长抑素类似物已经过测试,可用于神经内分泌肿瘤(NETs)患者的治疗监测。但是,肿瘤中的SUV与生长抑素受体表达的代表与净流入率(K i)不相关。在这项研究中,肿瘤血比(TBR)被评估为半定量评估68 Ga-DOTATOC和68 Ga- DOTATATE肿瘤摄取的替代工具,以及作为NETs患者的治疗监测工具。方法:22名NET患者在注射68 Ga-DOTATOC或68 Ga- DOTATATE后进行了45分钟的动态PET / CT扫描。ķ使用Patlak方法确定TBR,并计算40至45分钟间隔的TBR。结果:发现K i与TBR之间存在线性关系,对于68 Ga-DOTATOC和68 Ga- DOTATATE ,Pearson相关系数的平方分别为0.98和0.93 。结论: K i与TBR之间存在高度相关性。因此,TBR比SUV更能准确地反映生长抑素受体的密度,并被建议作为半定量评估68 Ga-DOTATOC和68 Ga- DOTATATE肿瘤摄取的首选指标。

更新日期:2020-02-03
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