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The roles of triiodothyronine and irisin in improving the lipid profile and directing the browning of human adipose subcutaneous cells.
Molecular and Cellular Endocrinology ( IF 3.8 ) Pub Date : 2020-02-03 , DOI: 10.1016/j.mce.2020.110744 Miriane de Oliveira 1 , Lucas Solla Mathias 1 , Bruna Moretto Rodrigues 1 , Bianca Gonçalves Mariani 1 , Jones Bernardes Graceli 2 , Maria Teresa De Sibio 1 , Regiane Marques Castro Olimpio 1 , Fernanda Cristina Fontes Moretto 1 , Igor Carvalho Deprá 1 , Célia Regina Nogueira 1
Molecular and Cellular Endocrinology ( IF 3.8 ) Pub Date : 2020-02-03 , DOI: 10.1016/j.mce.2020.110744 Miriane de Oliveira 1 , Lucas Solla Mathias 1 , Bruna Moretto Rodrigues 1 , Bianca Gonçalves Mariani 1 , Jones Bernardes Graceli 2 , Maria Teresa De Sibio 1 , Regiane Marques Castro Olimpio 1 , Fernanda Cristina Fontes Moretto 1 , Igor Carvalho Deprá 1 , Célia Regina Nogueira 1
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Triiodothyronine (T3) and irisin (I) can modulate metabolic status, increase heat production, and promote differentiation of white adipose tissue (WAT) into brown adipose tissue (BAT). Herein, human subcutaneous white adipocytes were treated with 10 nM T3 or 20 nM I for 24 h to evaluate intracellular lipid accumulation, triglyceride, and glycerol levels, oxidative stress, DNA damage, and protein levels of uncoupling protein 1 (UCP1), adiponectin, leptin, peroxisome proliferator-activated receptor gamma (PPARγ), and fibronectin type III domain-containing protein 5 (FNDC5). T3 and irisin improved UCP1 production, lipid profile, oxidative stress, and DNA damage. T3 elevated adiponectin and leptin levels with a concomitant decrease in PPARy and FNDC5 levels. However, irisin did not alter adipokine, PPARy, and FNDC5 levels. The results indicate that T3 may be used to increase leptin and adiponectin levels to improve insulin sensitivity, and irisin may be used to prevent obesity or maintain weight due to its impact on the lipid profile without altering adipokine levels.
中文翻译：
三碘甲状腺素和虹膜素在改善脂质分布和指导人脂肪皮下细胞褐变中的作用。
Triiodothyronine（T3）和Irisin（I）可以调节代谢状态，增加热量产生，并促进白色脂肪组织（WAT）向棕色脂肪组织（BAT）的分化。在此，将人类皮下白色脂肪细胞用10 nM T3或20 nM I处理24小时，以评估细胞内脂质蓄积，甘油三酸酯和甘油水平，氧化应激，DNA损伤以及解偶联蛋白1（UCP1），脂联素，瘦素，过氧化物酶体增殖物激活受体γ（PPARγ）和纤连蛋白III型域蛋白5（FNDC5）。T3和虹膜素改善了UCP1的产生，脂质分布，氧化应激和DNA损伤。T3脂联素和瘦素水平升高，PPARy和FNDC5水平随之降低。但是，鸢尾素并没有改变脂肪因子，PPARy和FNDC5的水平。
更新日期：2020-02-03
中文翻译：
三碘甲状腺素和虹膜素在改善脂质分布和指导人脂肪皮下细胞褐变中的作用。
Triiodothyronine（T3）和Irisin（I）可以调节代谢状态，增加热量产生，并促进白色脂肪组织（WAT）向棕色脂肪组织（BAT）的分化。在此，将人类皮下白色脂肪细胞用10 nM T3或20 nM I处理24小时，以评估细胞内脂质蓄积，甘油三酸酯和甘油水平，氧化应激，DNA损伤以及解偶联蛋白1（UCP1），脂联素，瘦素，过氧化物酶体增殖物激活受体γ（PPARγ）和纤连蛋白III型域蛋白5（FNDC5）。T3和虹膜素改善了UCP1的产生，脂质分布，氧化应激和DNA损伤。T3脂联素和瘦素水平升高，PPARy和FNDC5水平随之降低。但是，鸢尾素并没有改变脂肪因子，PPARy和FNDC5的水平。
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