African trypanosomes are mainly transmitted by tsetse flies. In recent years there has been good progress in understanding how the parasites prepare for transmission, detect their changed environment through the perception of different environmental cues, and respond by changing their developmental gene expression. In this review, we discuss the different signals and signaling mechanisms used by the parasites to carry out the early events necessary for their establishment in the fly. We also compare Trypanosoma brucei and Trypanosoma congolense, parasites that share a common pathway in the early stages of fly colonization but apparently use different mechanisms to achieve this.

中文翻译：

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向未知的飞跃-非洲锥虫传播的早期事件。

非洲锥虫主要通过采采蝇传播。近年来，在理解寄生虫如何准备传播，通过感知不同环境线索来检测其变化的环境以及通过改变其发育基因表达做出反应方面取得了良好的进展。在这篇综述中，我们讨论了寄生虫用于执行其动态建立所必需的早期事件的不同信号和信号传导机制。我们还比较了布鲁氏锥虫和锥虫锥虫，它们在果蝇定殖的早期阶段具有共同的途径，但显然使用不同的机制来实现这一目标。