Palladium‐Catalyzed Cascade Cyclization/Alkynylation of Alkene‐Tethered Carbamoyl Chlorides with Terminal Alkynes: Synthesis of Alkyne‐Functionalized Oxindoles,Asian Journal of Organic Chemistry

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Palladium‐Catalyzed Cascade Cyclization/Alkynylation of Alkene‐Tethered Carbamoyl Chlorides with Terminal Alkynes: Synthesis of Alkyne‐Functionalized Oxindoles
Asian Journal of Organic Chemistry ( IF 2.8 ) Pub Date : 2020-02-11 , DOI: 10.1002/ajoc.202000033
Wan Sun ₁ , Xiaonan Shi ₁ , Chen Chen ₁ , Yan‐Ping Zhu ₂ , Zhengyu Liu ₁ , Bolin Zhu ₁

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We reported the first palladium‐catalyzed copper‐free cascade cyclization/alkynylation of alkene‐tethered carbamoyl chlorides with terminal alkynes, which provided an alternative approach to synthesize various functionalized oxindoles bearing a propargyl all‐carbon quaternary center. This protocol was highly efficient and exhibited good functional group compatibility, as well as the broad substrate scope.

中文翻译：

钯催化的链烯基氨基甲酰氯与末端炔烃的级联环化/炔化反应：炔基官能化的吲哚的合成

我们报道了烯烃连接的氨基甲酰氯与末端炔烃的第一个钯催化的无铜级联环化/炔基化反应，这为合成带有炔丙基全碳四元中心的各种官能化吲哚提供了另一种方法。该协议是高效的，并且表现出良好的官能团兼容性，以及广泛的底物范围。

更新日期：2020-04-21

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