Aloe-emodin, which is isolated from Rheum palmatum L. and Aloe vera, has been proved to possess good antiproliferative activity. A series of Aloe-emodin derivatives were designed and synthesized; in addition, they were evaluated as inhibitors of proliferation of human breast adenocarcinoma (MDA-MB-231), human nonsmall cell lung carcinoma (A549), and human cervix carcinoma (HeLa) cells. The biological activity results showed that 4a , 4c , and 4d exhibited better antiproliferative activity than aloe-emodin for MDA-MB-231 cells at a concentration of 3 μM, and only 4a and 4d exhibited better antiproliferative activity for A549 cells at the same concentration level.

中文翻译：

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芦荟大黄素的合成衍生物作为人乳腺癌、人非小细胞肺癌和人子宫颈癌的增殖抑制剂

从大黄和芦荟中分离出的芦荟大黄素已被证明具有良好的抗增殖活性。设计合成了一系列芦荟大黄素衍生物；此外，它们被评估为人类乳腺腺癌 (MDA-MB-231)、人类非小细胞肺癌 (A549) 和人类子宫颈癌 (HeLa) 细胞增殖的抑制剂。生物活性结果表明4a、4c、4d对MDA-MB-231细胞3 μM的抗增殖活性优于芦荟大黄素，相同浓度下仅4a和4d对A549细胞具有更好的抗增殖活性等级。