In this paper, we prepared doxorubicin-loaded folic acid-functionalized pH-sensitive photothermal therapy (PTT) traceable hollow mesoporous silica nanoparticles (DOX-HPCF) as a drug carrier for liver cancer treatment. According to TEM characterization, hollow mesoporous silica nanoparticles (HMSN) are monodispersed spherical particles with hollow structure. In vitro drug release experiments showed that HPCF exhibited pH-sensitive release. Cell uptake experiments showed that HPCF was successfully absorbed by SMMC-7721 cells. In addition, DOX-HPCF significantly inhibited the proliferation of SMMC-7721 cells, and the near-infrared (NIR) light group showed a more obvious inhibitory effect. In vivo anti-tumor experiments showed that DOX-HPCF-assisted PTT inhibited tumor growth significantly. Therefore, HPCF is a promising photothermotherapy carrier for the treatment of liver cancer.

中文翻译：

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叶酸功能化的pH敏感光热疗法可追踪的中空介孔二氧化硅纳米粒子作为靶向药物载体，可改善阿霉素在肝癌细胞系SMMC-7721中的抗肿瘤作用。

在本文中，我们制备了负载阿霉素的叶酸官能化pH敏感光热疗法（PTT）可追溯的中空介孔二氧化硅纳米粒子（DOX-HPCF）作为肝癌治疗的药物载体。根据TEM表征，中空介孔二氧化硅纳米颗粒（HMSN）是具有中空结构的单分散球形颗粒。体外药物释放实验表明，HPCF表现出对pH敏感的释放。细胞摄取实验表明HPCF被SMMC-7721细胞成功吸收。此外，DOX-HPCF显着抑制SMMC-7721细胞的增殖，而近红外（NIR）灯组显示出更明显的抑制作用。体内抗肿瘤实验表明，DOX-HPCF辅助的PTT显着抑制肿瘤生长。因此，