Redox-Responsive Polycondensate Neoepitope for Enhanced Personalized Cancer Vaccine,ACS Central Science

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Redox-Responsive Polycondensate Neoepitope for Enhanced Personalized Cancer Vaccine
ACS Central Science ( IF 12.7 ) Pub Date : 2020-02-03 , DOI: 10.1021/acscentsci.9b01174
Lixia Wei ₁ , Yu Zhao ₂ , Xiaomeng Hu ₂ , Li Tang _{1,

2}

Affiliation

A versatile and highly effective platform remains a major challenge in the development of personalized cancer vaccines. Here, we devised a redox-responsive polycondensate neoepitope (PNE) through a reversible polycondensation reaction of peptide neoantigens and adjuvants together with a tracelessly responsive linker-monomer. Peptide-based neoantigens with diverse sequences and structures could be copolymerized with molecular adjuvants to form PNEs of high loading capacity for vaccine delivery without adding any carriers. The redox-responsive PNEs with controlled molecular weights and sizes efficiently targeted and accumulated in draining lymph nodes and greatly promoted the antigen capture and cross-presentation by professional antigen presenting cells. Mice immunized with PNEs showed markedly enhanced antigen-specific T cell response and the protective immunity against the tumor cell challenge.

中文翻译：

氧化还原反应性缩合物新表位用于增强个性化癌症疫苗

多功能且高效的平台仍然是个性化癌症疫苗开发的主要挑战。在这里，我们设计了一种通过肽新抗原和佐剂与无痕响应的接头单体的可逆缩聚反应设计的氧化还原反应性缩聚物新表位（PNE）。可以将具有不同序列和结构的基于肽的新抗原与分子佐剂共聚，以形成高负载能力的PNE，从而无需添加任何载体即可递送疫苗。具有受控分子量和大小的氧化还原反应性PNE有效地靶向并积聚在引流淋巴结中，并极大地促进了专业抗原呈递细胞的抗原捕获和交叉呈递。

更新日期：2020-03-26

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