CHIT1 at diagnosis reflects long‐term multiple sclerosis disease activity,Annals of Neurology

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CHIT1 at diagnosis reflects long‐term multiple sclerosis disease activity
Annals of Neurology ( IF 8.1 ) Pub Date : 2020-04-01 , DOI: 10.1002/ana.25691
Emanuela Oldoni _{1,

2} , Ide Smets _{1,

2,

3} , Klara Mallants _{1,

2} , Marijne Vandebergh _{1,

2} , Lies Van Horebeek _{1,

2} , Koen Poesen _{2,

4} , Patrick Dupont _{2,

5} , Bénédicte Dubois _{1,

2,

3} , An Goris _{1,

2}

Affiliation

Evidence for a role of microglia in the pathogenesis of multiple sclerosis (MS) is growing. We investigated association of microglial markers at time of diagnostic lumbar puncture (LP) with different aspects of disease activity (relapses, disability, magnetic resonance imaging parameters) up to 6 years later in a cohort of 143 patients.

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