The Design of Sulfobetaine Polymers with Thermoresponsiveness under Physiological Salt Conditions,Macromolecular Chemistry and Physics

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The Design of Sulfobetaine Polymers with Thermoresponsiveness under Physiological Salt Conditions
Macromolecular Chemistry and Physics ( IF 2.5 ) Pub Date : 2020-01-30 , DOI: 10.1002/macp.201900429
Nobuyuki Morimoto ₁ , Yoshifumi Oishi ₁ , Masaya Yamamoto _{1,

2}

Affiliation

Thermoresponsive polymers are attractive in terms of basics and applications because of the phase separation in aqueous solution. Some sulfobetaine polymers are known for their antifouling biocompatibility and upper critical solution temperature (UCST) type thermoresponsiveness; however, thermoresponsiveness disappears in aliphatic sulfobetaine polymers in physiological salt conditions. Aromatic cation‐containing sulfobetaine polymers are not responded because of the strong intermolecular interactions. In this study, new sulfobetaine methacrylamides with a pyridinium cation, 3‐(4‐(2‐methacrylamido)alkyl pyridinio‐1‐yl)propane‐1‐sulfonates, (PySMAAm)s, are designed and then prepared the homopolymers using aqueous reversible addition‐fragmentation chain transfer polymerization. The P(PySMAAm)s exhibited UCST‐type thermoresponsiveness that is induced by substitution of the dipole–dipole interaction between the interpolymer side chain to an ion–dipole interaction in physiological salt conditions. The thermoresponsiveness is affected by the molecular weight and structure of the side chains. Such sulfobetaine polymers can be promising tools as biomaterials especially for drug delivery and regenerative medicine.

中文翻译：

生理盐条件下具有热响应性的磺基甜菜碱聚合物的设计

由于在水溶液中的相分离，热敏性聚合物在基础和应用方面具有吸引力。一些磺基甜菜碱聚合物因其防污生物相容性和上临界溶液温度（UCST）类型的热响应性而闻名。然而，在生理盐条件下，脂族磺基甜菜碱聚合物的热响应性消失了。由于强烈的分子间相互作用，含芳族阳离子的磺基甜菜碱聚合物没有反应。在这项研究中，设计了带有吡啶鎓阳离子的新磺基甜菜碱甲基丙烯酰胺，3-（4-（2-（2-甲基丙烯酰胺基）烷基吡啶基-1-基）丙烷-1-磺酸盐（PySMAAm），然后使用可逆水溶液制备均聚物加成-断裂链转移聚合。P（PySMAAm）表现出UCST型热响应性，这是通过在生理盐条件下将互聚物侧链之间的偶极-偶极相互作用替换为离子-偶极相互作用而引起的。热响应性受侧链的分子量和结构影响。这样的磺基甜菜碱聚合物可以作为生物材料有希望的工具，特别是用于药物递送和再生医学的生物材料。

更新日期：2020-01-30

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