This study was performed to investigate the effects of highly bioavailable curcumin as Theracurmin® (TC) in rats with monosodium iodoacetate (MIA)-induced osteoarthritis (OA). Seventy-seven male Wistar rats were divided into six groups: normal, negative control (MIA only), positive control (Cerebrex), and three experimental groups treated with 500, 1300, or 2600 mg/kg of TC for 5 weeks. MIA injection-induced OA caused 30% weight-bearing imbalance whereas weight bearing imbalance was significantly improved in the TC groups. Mankin scores revealed TC treatment had significantly ameliorated cartilage damage and chondrocyte decrease. The expressions of nitrotyrosine, tumor necrosis factor-α, phosphorylated nuclear factor kappa B cells, and cleaved caspase-3 were markedly increased in rat with MIA-induced OA, but the TC-treated groups exhibited a significant reduction in the number of immunoreactive cells in a dose-dependent manner. In conclusion, administration of TC contributes to the anti-arthritic effect in rat with MIA-induced OA.

中文翻译：

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具有高生物利用度的姜黄素粉可抑制碘代乙酸盐（MIA）诱导的骨关节炎大鼠的关节软骨损伤。

进行这项研究的目的是研究高生物利用姜黄素（Theracurmin®（TC））在碘乙酸单钠（MIA）诱发的骨关节炎（OA）大鼠中的作用。将77只雄性Wistar大鼠分为六组：正常，阴性对照组（仅MIA），阳性对照组（Cerebrex）和三个实验组，分别以500、1300或2600 mg / kg的TC处理5周。MIA注射诱导的OA导致30％的负重失衡，而TC组的负重失衡得到显着改善。Mankin评分显示TC治疗显着改善了软骨损伤和软骨细胞减少。在MIA诱导的OA大鼠中，硝基酪氨酸，肿瘤坏死因子-α，磷酸化的核因子κB和裂解的caspase-3的表达明显增加，但TC治疗组的免疫反应性细胞数量呈剂量依赖性显着降低。总之，TC的添加有助于MIA诱导的OA大鼠的抗关节炎作用。