Normal cardiac function requires that intracellular Ca2+ concentration be reduced to low levels in diastole so that the ventricle can relax and refill with blood. Heart failure is often associated with impaired cardiac relaxation. Little, however, is known about how diastolic intracellular Ca2+ concentration is regulated. This article first discusses the reasons for this ignorance before reviewing the basic mechanisms that control diastolic intracellular Ca2+ concentration. It then considers how the control of systolic and diastolic intracellular Ca2+ concentration is intimately connected. Finally, it discusses the changes that occur in heart failure and how these may result in heart failure with preserved versus reduced ejection fraction.

中文翻译：

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心脏中舒张钙的控制：基本机制和功能含义。

正常的心脏功能要求将舒张期的细胞内Ca2 +浓度降低至低水平，以使心室放松并补充血液。心力衰竭通常与心脏松弛受损有关。然而，关于舒张期细胞内Ca 2+浓度是如何调节的知之甚少。这篇文章首先讨论这种无知的原因，然后再回顾控制舒张期细胞内Ca2 +浓度的基本机制。然后考虑如何密切控制收缩期和舒张期细胞内Ca2 +浓度。最后，它讨论了心力衰竭发生的变化，以及这些变化如何导致射血分数保持相对降低的心力衰竭。