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Chromatin plasticity eXISTs in differentiated cells.
Nature Reviews Molecular Cell Biology ( IF 81.3 ) Pub Date : 2020-03-01 , DOI: 10.1038/s41580-020-0221-4
Minju Ha 1
Affiliation  

Extopic expression of the XIST RNA at one chromosome 21 in iPSCs derived from individuals with Down syndrome leads to transcriptional silencing of chromosome 21 and improves iPSC differentiation into neurons.

中文翻译:

分化细胞中的染色质可塑性eXIST。

在患有唐氏综合症的个体的iPSC中,XIST RNA在一条21号染色体上的外源表达导致21号染色体的转录沉默,并改善了iPSC向神经元的分化。
更新日期:2020-01-30
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