The interest in helix-containing nanostructures is currently growing as a consequence of their potential applications in areas such as nanomedicine, nanomaterial design, chiral recognition, and asymmetric catalysis. Herein, we present a facile and tunable one-pot methodology to achieve chiral nano-objects. The nickel-catalyzed coordination polymerization-induced self-assembly (NiCCo-PISA) of helical poly(aryl isocyanide) amphiphilic diblock copolymers was realized and allowed access to various nano-object morphologies (spheres, worm-like micelles, and polymersomes). The helicity of the core block was confirmed via circular dichroism (CD) spectroscopy for all morphologies, proving their chiral nature. Small-molecule uptake by the spherical nanoparticles was investigated by encapsulating Nile Red into the core of the spheres and subsequent transfer into aqueous media. The presence of a CD signal for the otherwise CD-inactive dye proved the chiral induction effect of the nano-objects’ helical core. This demonstrates the potential of NiCCo-PISA to prepare nanoparticles for applications in nanomaterials, catalysis, and recognition.

中文翻译：

---

镍催化配位聚合诱导螺旋聚芳基异氰化物的自组装

由于其在纳米医学、纳米材料设计、手性识别和不对称催化等领域的潜在应用，目前对含螺旋纳米结构的兴趣正在增长。在这里，我们提出了一种简单且可调节的一锅法来实现手性纳米物体。实现了螺旋聚（芳基异氰化物）两亲二嵌段共聚物的镍催化配位聚合诱导自组装（NiCCo-PISA），并允许获得各种纳米物体形态（球体、蠕虫状胶束和聚合物体）。核心块的螺旋性通过所有形态的圆二色 (CD) 光谱得到证实，证明了它们的手性性质。通过将尼罗红封装到球体的核心并随后转移到水性介质中来研究球形纳米颗粒对小分子的吸收。否则 CD 非活性染料的 CD 信号的存在证明了纳米物体的螺旋核心的手性诱导效应。这证明了 NiCCo-PISA 在制备用于纳米材料、催化和识别的纳米粒子方面的潜力。