A commentary on our manuscript ‘Genomic landscape of inverted urothelial papilloma and urothelial papilloma of the bladder’ was recently published in the Journal of Pathology. In their manuscript, the authors highlighted the major findings of our study including the distinct genetic profiles of inverted urothelial papilloma and urothelial papilloma compared to urothelial carcinoma. They also pointed to a lack of comparison in our study between inverted urothelial papilloma (IUP) and noninvasive urothelial carcinoma with inverted growth (iUC). In this letter, we address this point and provide data to support that the genetic profiles of iUC are distinct from that of IUP.

中文翻译：

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倒置尿路上皮乳头状瘤和倒置生长的尿路上皮癌在组织学和分子上是不同的实体。

对我们的手稿“倒置尿路上皮乳头状瘤和膀胱尿路上皮乳头状瘤的基因组景观”的评论最近发表在《病理学杂志》上。在他们的手稿中，作者强调了我们研究的主要发现，包括倒置尿路上皮乳头状瘤和尿路上皮乳头状瘤与尿路上皮癌相比的独特遗传特征。他们还指出，我们的研究缺乏对内翻性尿路上皮乳头状瘤（IUP）和内翻性生长的非浸润性尿路上皮癌（iUC）的比较。在这封信中，我们讨论了这一点，并提供数据来支持 iUC 的遗传图谱与 IUP 的不同。