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Butyrate Inhibits Deoxycholic-Acid-Resistant Colonic Cell Proliferation via Cell Cycle Arrest and Apoptosis: A Potential Pathway Linking Dietary Fiber to Cancer Prevention.
Molecular Nutrition & Food Research ( IF 4.5 ) Pub Date : 2020-02-27 , DOI: 10.1002/mnfr.201901014 Huawei Zeng 1 , Bryan D Safratowich 1 , Thomas T Y Wang 2 , Stephanie K Hamlin 1 , LuAnn K Johnson 1
Molecular Nutrition & Food Research ( IF 4.5 ) Pub Date : 2020-02-27 , DOI: 10.1002/mnfr.201901014 Huawei Zeng 1 , Bryan D Safratowich 1 , Thomas T Y Wang 2 , Stephanie K Hamlin 1 , LuAnn K Johnson 1
Affiliation
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Butyrate, an intestinal microbiota metabolite of dietary fiber, exhibits colon cancer preventive effects. In contrast, a high fat intake increases fecal secondary bile acids, such as deoxycholic acid (DCA, a potential cancer promoter), which selectively enrich mutant epithelial cells with an abnormally high resistance to DCA‐induced apoptosis in the colon. This study is conducted to test the hypothesis that physiological concentrations of butyrate inhibit DCA‐resistant colonic cell proliferation.
中文翻译：
丁酸酯通过细胞周期阻滞和凋亡抑制抗氧胆酸的结肠细胞增殖：将膳食纤维与癌症预防联系起来的潜在途径。
丁酸盐是膳食纤维的肠道微生物群代谢产物，具有预防结肠癌的作用。相反，高脂肪摄入会增加粪便中的次级胆汁酸，例如脱氧胆酸（DCA，一种潜在的癌症促进剂），从而选择性地富集突变上皮细胞，并对DCA诱导的结肠细胞凋亡具有异常高的抵抗力。进行这项研究的目的是检验丁酸的生理浓度抑制DCA耐药结肠细胞增殖的假说。
更新日期：2020-02-27
中文翻译：
丁酸酯通过细胞周期阻滞和凋亡抑制抗氧胆酸的结肠细胞增殖：将膳食纤维与癌症预防联系起来的潜在途径。
丁酸盐是膳食纤维的肠道微生物群代谢产物，具有预防结肠癌的作用。相反，高脂肪摄入会增加粪便中的次级胆汁酸，例如脱氧胆酸（DCA，一种潜在的癌症促进剂），从而选择性地富集突变上皮细胞，并对DCA诱导的结肠细胞凋亡具有异常高的抵抗力。进行这项研究的目的是检验丁酸的生理浓度抑制DCA耐药结肠细胞增殖的假说。
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