Radial glia (RG) cells are the first neural stem cells to appear during embryonic development. Adult human glioblastomas harbor a subpopulation of RG-like cells with typical RG morphology and markers. The cells exhibit the classic and unique mitotic behavior of normal RG in a cell-autonomous manner. Single-cell RNA sequencing analyses of glioblastoma cells reveal transcriptionally dynamic clusters of RG-like cells that share the profiles of normal human fetal radial glia and that reside in quiescent and cycling states. Functional assays show a role for interleukin in triggering exit from dormancy into active cycling, suggesting a role for inflammation in tumor progression. These data are consistent with the possibility of persistence of RG into adulthood and their involvement in tumor initiation or maintenance. They also provide a putative cellular basis for the persistence of normal developmental programs in adult tumors.

放射状胶质细胞（RG）是胚胎发育过程中第一个出现的神经干细胞。成人胶质母细胞瘤含有 RG 样细胞亚群，具有典型的 RG 形态和标记。这些细胞以细胞自主的方式表现出正常 RG 的经典且独特的有丝分裂行为。胶质母细胞瘤细胞的单细胞 RNA 测序分析揭示了 RG 样细胞的转录动态簇，这些细胞具有正常人胎儿放射状胶质细胞的特征，并且处于静止和循环状态。功能测定显示白细胞介素在触发从休眠状态退出到活跃循环中的作用，表明炎症在肿瘤进展中的作用。这些数据与 RG 持续到成年的可能性及其参与肿瘤发生或维持的可能性一致。它们还为成人肿瘤中正常发育程序的持续存在提供了假定的细胞基础。