Neuroimaging research has shown that patients with obsessive-compulsive disorder (OCD) may present brain structural and functional alterations, but the results across imaging modalities and task paradigms are difficult to reconcile. Are the same brain systems that are structurally different in OCD patients also involved in executive function and emotional processing? To answer this, we conducted separate meta-analyses of voxel-based morphometry studies, executive function functional magnetic resonance imaging (fMRI) studies, and emotional processing fMRI studies. Next, with a multimodal approach (conjunction analysis), we identified the common alterations across meta-analyses. Patients presented increased gray matter volume and hyperactivation in the putamen, but the putamen subregions affected differed depending on the psychological process. Left posterior/dorsal putamen showed hyperactivation during executive processing tasks, while predominantly right anterior/ventral putamen showed hyperactivation during emotional processing tasks. Interestingly, age was significantly associated with increased right putamen volume. Finally, the left dorsolateral prefrontal cortex was hyperactive in both functional domains. Our findings highlight task-specific correlates of brain structure and function in OCD and help integrate a growing literature.

中文翻译：

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强迫症的大脑结构和功能中特定于模式的重叠：病例对照MRI研究的多模式荟萃分析。

神经影像学研究表明，强迫症（OCD）患者可能会出现大脑结构和功能的改变，但跨影像学方法和任务范式的结果难以统一。在强迫症患者中结构相同的相同大脑系统是否也参与执行功能和情绪加工？为了回答这个问题，我们对基于体素的形态学研究，执行功能功能磁共振成像（fMRI）研究和情绪处理fMRI研究进行了单独的荟萃分析。接下来，采用多模式方法（合并分析），我们确定了荟萃分析中的常见变更。患者出现的灰质灰质量增加和壳核过度活化，但是受影响的壳核亚区取决于心理过程的不同。左后/背壳壳核在执行处理任务中表现出过度激活，而右前/腹壳壳核在情绪处理任务过程中表现出过度激活。有趣的是，年龄与右壳蛋白量增加显着相关。最后，左背外侧前额叶皮层在两个功能区域都活跃。我们的发现突出了强迫症中大脑结构和功能的特定任务相关性，并有助于整合不断增长的文献。左背外侧前额叶皮层在两个功能区域均活跃。我们的发现突出了强迫症中大脑结构和功能的特定任务相关性，并有助于整合不断增长的文献。左背外侧前额叶皮层在两个功能区域均活跃。我们的发现突出了强迫症中大脑结构和功能的特定任务相关性，并有助于整合不断增长的文献。