Glycogen synthase kinase-3 (GSK-3) regulates numerous signaling transductions and pathological states, from cell growth, inflammation, apoptosis, and heart failure to cancer. Recent studies have validated the feasibility of targeting GSK-3β for its therapeutic potential to maintain myocardial homeostasis. Herein, we review the multifactorial roles of GSK-3β in cardiac abnormalities, focusing primarily on recent investigations into myocardial survival. In addition, we discuss the cardioprotective potential of divergent GSK-3β inhibitors. Finally, we also highlight crosstalk between the various mechanisms underlying abnormal myocardial functions in which GSK-3β is involved.

中文翻译：

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GSK-3β在心肌疾病中的信号相互作用。

糖原合酶激酶3（GSK-3）调节多种信号转导和病理状态，从细胞生长，炎症，凋亡，心力衰竭到癌症。最近的研究已经证实了针对GSK-3β维持心肌动态平衡的治疗潜力的可行性。本文中，我们综述了GSK-3β在心脏异常中的多因素作用，主要侧重于对心肌存活的最新研究。此外，我们讨论了不同的GSK-3β抑制剂的心脏保护潜力。最后，我们还强调了涉​​及GSK-3β的异常心肌功能的各种机制之间的串扰。