BACKGROUND Quality of life (QoL) after hepatic resection is a pertinent issue that has been poorly studied. The aim of this study was to compare changes in QoL before and after hepatic resection. METHODS A systematic review was performed using Medline, EMBASE, and the Cochrane library. Whenever possible, pooled mean differences of survey scores pre- and post-operatively were calculated. RESULTS 22 studies were included comprising a total of 1785 participants. Using the EORTC-QLQ 30C survey, patients with benign disease tend to have better QoL post-surgery than those with malignant disease. There were post-operative improvements in the following FACT-HEP domains: physical at 9 months (MD 3.14, 95%CI 2.70 to 3.58, P < 0.001), social and family at 3 (MD 1.45, 95%CI 0.12 to 2.77, p = 0.030), 6 (MD 1.12, 95%CI 0.21 to 2.04, p = 0.020), 9 (MD 0.66, 95%CI 0.03 to 1.28, p = 0.040), and 12 (MD 0.58, 95%CI 0.12 to 1.03, p = 0.010) months, emotional at 9 (P < 0.001) and 24 months (P < 0.001), hepatobiliary at 24 months (p < 0.001), and global health status at 9 months (p = 0.002). CONCLUSION QoL scores tend to deteriorate post-surgery, but recover to baseline in the long-term at 9-months. Patients with malignant disease, and those who underwent major hepatectomy, have poorer QoL scores.

中文翻译：

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对肝切除术后生活质量的系统评价和荟萃分析。

背景技术肝切除术后的生活质量（QoL）是一个相关的问题，目前尚未得到充分研究。这项研究的目的是比较肝切除术前后的QoL变化。方法使用Medline，EMBASE和Cochrane库进行系统的审查。尽可能计算术前和术后调查分数的合并平均差。结果共纳入22项研究，共1785名参与者。使用EORTC-QLQ 30C调查，与恶性疾病患者相比，良性疾病患者的术后QoL往往更好。下列FACT-HEP领域的术后状况有所改善：9个月时身体健康（MD 3.14，95％CI 2.70至3.58，P <0.001），3岁时社交和家庭（MD 1.45，95％CI 0.12至2.77， p = 0.030），6（MD 1.12、95％CI 0.21至2.04，p = 0.020），9（MD 0.66，95％CI 0.03至1.28，p = 0.040）和12（MD 0.58，95％CI 0.12至1.03，p = 0.010）月，9（P <0.001）和24个月（P <0.001）时情绪激动24个月（p <0.001），以及9个月时的整体健康状况（p = 0.002）。结论QoL评分往往会使术后恶化，但长期在9个月后恢复到基线水平。患有恶性疾病的患者和接受大肝切除术的患者的QoL评分较差。