The aims of this work were to assess the PAH exposure among, roofers and to identify relevant biomarkers for monitoring occupational,exposure. Several campaigns were conducted between 2004 and 2017, with 28,individual air samples and 240 urinary samples collected from 73 roofers. Seventeen parent PAHs and 14 urinary biomarkers, metabolites of pyrene (1-OHP), benzo(a)pyrene (3-OHBaP and TetraolBaP), naphthalene (1- and 2-naphtols), fluorene (1-2-3-9-fluorenols) and phenanthrene (1-2-3-4-9-phenanthrols), were analysed. Three exposure groups were considered: soft-applied roofing using polymer-modified bitumen ("PMB"), hot-applied roofing using oxidized bitumen ("OB") and the tearing off of old roof coatings containing coal tar ("CT"). The PAHs containing 2-3 rings were much more abundant, and the highest airborne levels were observed in the "CT" group. The biomonitoring results were consistent with these results, with a large predominance of 2-3 ring PAH metabolites. 1-OHP, 3-fluorenol and 2-phenanthrol were better correlated with airborne levels and less influenced by smoking than the other metabolites. Conversely, 1-/2-naphtol levels were heavily influenced by smoking and not correlated with airborne naphthalene levels. Moreover, 3-OHBaP and TetraolBaP levels were very low when applying bitumen membranes, and much higher exposures were observed during tear-off activities. In this context, the recommended strategy for roofer biomonitoring should include 1-OHP, fluorenols and phenanthrols, as well as carcinogenic BaP metabolites (3-OHBaP or TetraolBaP) when evaluating the occupational exposure of roofers that are tearing off old roof coatings.

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评估屋顶职业暴露于 PAHS 的推荐生物监测策略

这项工作的目的是评估屋顶工人之间的 PAH 暴露，并确定相关的生物标志物以监测职业暴露。2004 年至 2017 年期间开展了多项活动，从 73 名屋顶工收集了 28 个个人空气样本和 240 个尿液样本。17 种母体 PAH 和 14 种尿液生物标志物、芘 (1-OHP)、苯并 (a) 芘（3-OHBaP 和 TetraolBaP）、萘（1- 和 2-萘酚）、芴（1-2-3-9-）的代谢物芴醇）和菲（1-2-3-4-9-菲酚）进行了分析。考虑了三个暴露组：使用聚合物改性沥青（“PMB”）的软应用屋顶、使用氧化沥青（“OB”）的热应用屋顶和撕掉含有煤焦油的旧屋顶涂料（“CT”）。含有 2-3 个环的多环芳烃要丰富得多，在“CT”组中观察到最高的空气传播水平。生物监测结果与这些结果一致，2-3 环多环芳烃代谢物占优势。与其他代谢物相比，1-OHP、3-芴醇和 2-菲酚与空气传播水平的相关性更好，受吸烟的影响更小。相反，1-/2-萘酚水平受吸烟影响很大，与空气中萘水平无关。此外，使用沥青膜时 3-OHBaP 和 TetraolBaP 水平非常低，并且在撕下活动期间观察到更高的暴露量。在这种情况下，屋顶生物监测的推荐策略应包括 1-OHP、芴醇和菲酚，