Effects of COMT rs4680 and BDNF rs6265 polymorphisms on brain degree centrality in Han Chinese adults who lost their only child.,Translational Psychiatry

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Effects of COMT rs4680 and BDNF rs6265 polymorphisms on brain degree centrality in Han Chinese adults who lost their only child.
Translational Psychiatry ( IF 5.8 ) Pub Date : 2020-01-30 , DOI: 10.1038/s41398-020-0728-7
Rongfeng Qi _{1,

2} , Yifeng Luo ₃ , Li Zhang ₄ , Yifei Weng ₁ , Wesley Surento ₂ , Lingjiang Li ₄ , Zhihong Cao ₃ , Guang Ming Lu ₁

Affiliation

Losing one's only child is a major traumatic life event that may lead to posttraumatic stress disorder (PTSD); however, not all parents who experience this trauma develop PTSD. Genetic variants are associated with the risk of developing PTSD. Catechol-O-methyltransferase (COMT) rs4680 and brain-derived neurotrophic factor (BDNF) rs6265 are two most well-described single-nucleotide polymorphisms that relate to stress response; however, the neural mechanism underlying their effects on adults who lost an only child remains poorly understood. Two hundred and ten Han Chinese adults who had lost their only child (55 with PTSD and 155 without PTSD) were included in this imaging genetics study. Participants were divided into subgroups according to their COMT rs4680 and BDNF rs6265 genotypes. Degree Centrality (DC)-a resting-state fMRI index reflecting the brain network communication-was compared with a three-way (PTSD diagnosis, COMT, and BDNF polymorphisms) analysis of covariance. Diagnosis state had a significant effect on DC in bilateral inferior parietal lobules and right middle frontal gyrus (MFG), where PTSD adults showed weaker DC. BDNF × diagnosis interaction effect was found in the right MFG and hippocampus, and these two regions were reversely modulated. Also, there was a significant COMT × BDNF interaction effect in left cuneus, middle temporal gyrus, right inferior occipital gyrus, and bilateral putamen, independent of PTSD diagnosis. These findings suggest that the modulatory effect of BDNF polymorphism on the MFG and hippocampus may contribute to PTSD development in bereaved adults. Interactions of COMT × BDNF polymorphisms modulate some cortices and basal ganglia, irrespective of PTSD development.

中文翻译：

COMT rs4680和BDNF rs6265多态性对失去独生子女的汉族成年人脑度中心性的影响。

失去独生子是重大的创伤性生活事件，可能导致创伤后应激障碍 (PTSD)；然而，并非所有经历过这种创伤的父母都会患上创伤后应激障碍。遗传变异与发生 PTSD 的风险相关。儿茶酚-O-甲基转移酶 (COMT) rs4680 和脑源性神经营养因子 (BDNF) rs6265 是与应激反应相关的两个最充分描述的单核苷酸多态性；然而，它们对失去独生子女的成年人影响的神经机制仍然知之甚少。210 名失去独生子女的汉族成年人（55 名患有 PTSD 和 155 名没有 PTSD）被纳入这项影像遗传学研究。根据他们的 COMT rs4680 和 BDNF rs6265 基因型将参与者分为亚组。度中心性 (DC) - 反映大脑网络通信的静息状态 fMRI 指数 - 与协方差的三向（PTSD 诊断、COMT 和 BDNF 多态性）分析进行了比较。诊断状态对双侧顶下小叶和右侧额中回（MFG）的DC有显着影响，其中PTSD成人表现出较弱的DC。在右侧MFG和海马中发现BDNF×诊断交互作用，并且这两个区域被反向调制。此外，在左侧楔叶、颞中回、右侧枕下回和双侧壳核中存在显着的 COMT × BDNF 相互作用效应，与 PTSD 诊断无关。这些研究结果表明，BDNF 多态性对 MFG 和海马的调节作用可能有助于失去亲人的成年人的 PTSD 发展。

更新日期：2020-01-31

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